推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous glycerol solution
分子量
antigen 53 kDa
物種活性
mouse, human
技術
microarray: suitable
western blot (chemiluminescent): 1:1,000 using p53 fusion proteins with CKII phosphorylation or an extract of hydroxyurea-treated MvILu cells
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... TP53(7157)
mouse ... Trp53(22059)
一般說明
p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.
特異性
Does not react with non-phosphorylated p53.
免疫原
synthetic peptide corresponding to residues around Ser392 of human p53 conjugated to KLH.
生化／生理作用
Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.
外觀
Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol
準備報告
Purified using protein A and peptide affinity chromatography.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Cell Cycle and Apoptosis
Bruna Pucci
Neoplasia, 2(4) (2000)
Cooper GM.
The Cell: A Molecular Approach (2000)
Chromosomal Instability andTumors Promoted by DNAHypomethylation
Amir Eden
Science, 30 (2003)
Cell Cycle and Apoptosis
Bruna Pucci
Neoplasia, 2(4) (2000)
Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1 (p53) deletions
Hong Chang
British Journal of Haematology, 127(3), 280?284-280?284 (2004)
商品
p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.
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