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P0130

Sigma-Aldrich

黄体酮

≥99% (HPLC), powder, maturation of the uterine endothelium inducer

别名:

4-孕烯-3,20-二酮

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About This Item

经验公式（希尔记法）:
C21H30O2
CAS号:
57-83-0
分子量:
314.46
Beilstein:
1915950
EC號碼:
200-350-6
MDL號碼:
MFCD00003658
分類程式碼代碼:
51111800
PubChem物質ID:
24278618
NACRES:
NA.77

product name

黄体酮, ≥99%

生物源

synthetic (organic)

品質等級

200

無菌

non-sterile

化驗

≥99%

形狀

powder

mp

128-132 °C (lit.)

溶解度

chloroform: 50 mg/mL, clear, colorless to light yellow

起源

Abbott

運輸包裝

ambient

儲存溫度

room temp

SMILES 字串

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChI 密鑰

RJKFOVLPORLFTN-LEKSSAKUSA-N

基因資訊

human ... ABCB1(5243) , AR(367) , CYP2C9(1559) , EBP(10682) , ESR1(2099) , ESR2(2100) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208) , Nr3c1(24413) , Pgr(25154)

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生化／生理作用

诱导子宫内皮细胞的成熟和分泌活性；抑制排卵。 孕激素与乳腺癌发病有关。

特點和優勢

该化合物由 Abbott开发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单， 请单击此处。

其他說明

黄体分泌的类固醇激素。

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H351,H360FD,H362

危險分類

Carc. 2 - Lact. - Repr. 1A

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

分析证书(COA)

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Alicia T Pate et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 317(2), R328-R336 (2019-05-30)
Nesfatin-1 is a peptide derived from the nucleobindin 2 (Nucb2) precursor protein that has been shown to exert potent effects on appetite and cardiovascular function in male animals. Sex hormones modulate the expression of Nucb2 in several species, including goldfish
Nina Lisofsky et al.
NeuroImage, 118, 154-162 (2015-06-10)
Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle. However, little is known about the covariation of hormone levels and brain structure in the course of the human menstrual cycle.
Danijela Konforte et al.
Clinical chemistry, 59(8), 1215-1227 (2013-05-03)
Pediatric endocrinopathies are commonly diagnosed and monitored by measuring hormones of the hypothalamic-pituitary-gonadal axis. Because growth and development can markedly influence normal circulating concentrations of fertility hormones, accurate reference intervals established on the basis of a healthy, nonhospitalized pediatric population
Rudolf Kaaks et al.
International journal of cancer, 134(8), 1947-1957 (2013-10-25)
Results from prospective studies on premenopausal serum hormone levels in relation to breast cancer risk have been inconclusive, especially with regard to tumor subtypes. Using a case-control study nested within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC)
Rudolf Kaaks et al.
Journal of the National Cancer Institute, 97(10), 755-765 (2005-05-19)
Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone deficiency, estrogen excess, estrogen and progesterone excess, and both an excess or lack of adrenal androgens (dehydroepiandrosterone
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