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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
red to brown
溶解度
DMSO: 5 mg/mL, clear (warmed)
儲存溫度
−20°C
SMILES 字串
CCOC(=O)c1ccc(cc1)N2NC(=O)\C(=C/c3ccc(o3)[N+]([O-])=O)C2=O
InChI
1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9+
InChI 密鑰
ARGIPZKQJGFSGQ-UKTHLTGXSA-N
應用
PYR-41已被用作E1抑制剂：
- 用于确定腺相关病毒（AAV）转导的细胞降解途径
- 通过基质辅助激光解吸/电离飞行时间（MALDI-TOF）E2/E3分析，评估其选择性和效力
- 处理高葡萄糖培养基中完全分化的C2C12肌管，以确定其对蛋白质泛素化和细胞活力的影响
- 预处理人脑微血管内皮细胞（hBMEC），用于细菌感染前的抑制研究
生化／生理作用
PYR-41是泛素活化酶（E1）的细胞渗透性抑制剂.
PYR-41是泛素活化酶（E1）的细胞渗透性抑制剂，对E3、E2或半胱天冬酶的活性几乎无活性或完全无活性。
PYR-41能够抑制E1泛素连接酶，如小鼠双微基因2同源物（MDM2）、痒同源物（ITCH）和HOIL-1L相互作用蛋白（HOIP）的E1泛素连接酶。 它具有潜在的抗癌作用。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Skin Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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