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474787

Sigma-Aldrich

MG-132

≥95% by HPLC, Potent, reversible, and cell-permeable proteasome inhibitor (Kᵢ = 4 nM).

别名:

Z-Leu-Leu-Leu-al, MG-132

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About This Item

经验公式（希尔记法）:
C26H41N3O5
CAS号:
133407-82-6
分子量:
475.62
MDL號碼:
MFCD00674886
分類程式碼代碼:
12352200
NACRES:
NA.77

产品名称

MG-132，HPLC检测显示纯度≥95%, Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).

品質等級

100

化驗

≥95% (HPLC)

形狀

powder

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

white

溶解度

DMSO: 25 mg/mL
ethanol: 25 mg/mL

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI 密鑰

TZYWCYJVHRLUCT-VABKMULXSA-N

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Amino Acid Sequence

Z-Leu-Leu-Leu-al

一般說明

高效、可逆和细胞渗透性蛋白酶体抑制剂抑制剂 (Ki = 4 nM)。通过26S复合物减少哺乳动物细胞和酵母的可渗透染色中泛素结合蛋白的降解，而不会影响其ATPase或异肽酶的活性。活化可启动细胞凋亡的c-Jun N-端激酶（JNK1）抑制NF-κB激活（IC50 = 3µM）。该材料经HPLC测试为≥95%纯。 还可提供经HPLC测试为≥98%纯（货号474790）的材料。还可以提供在DMSO（货号474788）中的20 mM溶液。

包裝

用惰性气体包装

警告

毒性：标准处理（A）

重構

溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他說明

Steinhilb, M.L., et al. 2001.J. Biol. Chem.276, 4476.
Meriin, A.B., et al. 1998.J. Biol. Chem. 273, 6373.
Adams, J., and Stein, R. 1996.Ann.Rep.Med. Chem.31, 279.
Klafki, H.W., et al. 1996.J. Biol. Chem.271, 2865.
Lee, D.H., and Goldberg, A.L., 1996.J. Biol. Chem.271, 27280.
Wiertz, E.J., et al. 1996.Cell84, 769.
Jensen, T.J., et al. 1995.Cell 83, 129.
Read, M.A., et al. 1995.Immunity2, 493.
Rock, K.L., et al. 1994.Cell 78, 761.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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