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N194

Sigma-Aldrich

NS-398

≥98% (HPLC), solid

别名:

N-[2-(环己氧基)-4-硝基苯基]甲磺酰胺

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About This Item

经验公式（希尔记法）:
C13H18N2O5S
CAS号:
123653-11-2
分子量:
314.36
MDL號碼:
MFCD00882995
分類程式碼代碼:
12352200
PubChem物質ID:
24897540
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

顏色

off-white

mp

127-128 °C

溶解度

DMSO: >5 mg/mL
H2O: insoluble

SMILES 字串

CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O

InChI

1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3

InChI 密鑰

KTDZCOWXCWUPEO-UHFFFAOYSA-N

基因資訊

human ... ALOX5(240) , CYP19A1(1588) , PTGS1(5742) , PTGS2(5743)
mouse ... Ptgs2(19225)

應用

NS-398作为环氧化酶2(COX2)抑制剂，已用于研究其：
  • 对斑马鱼胚胎心率的作用
  • 对大鼠心肌细胞凋亡和缺氧/复氧的作用
  • 对大鼠脂多糖(LPS)诱导厌食的作用

生化／生理作用

NS-398属于非甾体抗炎药(NSAID)。具有抗炎、镇痛和退烧作用。
选择性环加氧酶-2（COX-2）抑制剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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