M7945

Mephetyl tetrazole

≥98% (HPLC), oil

• 别名: 1-[2-(4-Methoxyphenyl)ethyl]-5-(1-p-tolylcyclopropyl)-1H-tetrazole
• 经验公式（希尔记法）: C₂₀H₂₂N₄O
• CAS号: 916923-10-9
• 分子量: 334.41
• MDL號碼: MFCD11045297
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329818044
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: oil
• 顏色: pale yellow
• 溶解度: DMSO: >5 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: COc1ccc(CCn2nnnc2C3(CC3)c4ccc(C)cc4)cc1
• InChI: 1S/C20H22N4O/c1-15-3-7-17(8-4-15)20(12-13-20)19-21-22-23-24(19)14-11-16-5-9-18(25-2)10-6-16/h3-10H,11-14H2,1-2H3
• InChI 密鑰: VREPWWBWXVLSEF-UHFFFAOYSA-N

说明

生化／生理作用

Mephetyl tetrazole is a potent and selective K_v1.5 potassium channel blocker.

Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC₅₀ = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.

特點和優勢

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)