684341

(S)-5-(吡咯烷-2-基)-1H-四唑

96%

• 别名: (S)-(–)-2-四唑-5-基吡咯烷, 脯氨酸四唑催化剂
• 经验公式（希尔记法）: C₅H₉N₅
• CAS号: 33878-70-5
• 分子量: 139.16
• MDL號碼: MFCD10000886
• 分類程式碼代碼: 12352005
• PubChem物質ID: 329760905
• NACRES: NA.22

属性

• 化驗: 96%
• 形狀: solid
• 光學活性: [α]20/D -9.0°, c = 1 in methanol
• mp: 253-258 °C
• SMILES 字串: C1CN[C@@H](C1)c2nnn[nH]2
• InChI: 1S/C5H9N5/c1-2-4(6-3-1)5-7-9-10-8-5/h4,6H,1-3H2,(H,7,8,9,10)/t4-/m0/s1
• InChI 密鑰: XUHYQIQIENDJER-BYPYZUCNSA-N

说明

應用

(S)-(−)-5-(2-Pyrrolidinyl)-1H-tetrazole can be used as an organocatalyst:

• To prepare enantioselective chiral 1,2-oxazines from achiral ketones via an intramolecular Wittig reaction.
• To synthesize diastereoselective Michael addition products by addition of aliphatic aldehydes to β-nitrostyrene.
• In the direct asymmetric α-fluorination of linear and branched aldehydes using N-fluorobenzenesulfonamide as the fluorinating agent.

Organocatalyst used for:

• Direct asymmetric aldol reactions between acetone and aldehydes yielding β -hydroxy ketone and for synthesizing 1,1,1-trichloro-2-alkanols
• Mannich reactions for synthesis fo α -amino acids and generation of 1,4-diamines
• Conjugate additions of malonates to enones

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301,H315,H319,H335
• 防範說明: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges