M5441
米贝拉地尔 二盐酸盐 水合物
≥98% (HPLC), powder, T-type Ca²⁺ channel blocker
别名:
(1S,2S)-2-[2[[3-(2-苯并咪唑基)丙基]甲基氨基]乙基]-6-氟-1,2,3,4-四氢-1-异丙基-2-萘基甲氧基乙酸酯 二盐酸盐 水合物, Ro 40-5967 水合物
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About This Item
经验公式（希尔记法）:
C29H38FN3O3 · 2HCl · xH2O
CAS号:
分子量:
568.55 (anhydrous basis)
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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product name
米贝拉地尔 二盐酸盐 水合物, ≥98% (HPLC), powder
品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white
溶解度
H2O: soluble >20 mg/mL
absolute ethanol: insoluble
起源
Roche
SMILES 字串
O.Cl.Cl.COCC(=O)O[C@]3(CCN(C)CCCc1nc2ccccc2[nH]1)CCc4cc(F)ccc4[C@@H]3C(C)C
InChI
1S/C29H38FN3O3.2ClH.H2O/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H;1H2/t28-,29-;;;/m0.../s1
InChI 密鑰
IZSWBBGKLWFDOC-YKXHUFBBSA-N
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Mibefradil block of cloned T-type calcium channels
Martin R L, et al.
Journal of Pharmacology and Experimental Therapeutics, 295(1), 302-308 (2000)
Bobbi-Jo Lowie et al.
American journal of physiology. Gastrointestinal and liver physiology, 301(5), G835-G845 (2011-08-13)
Interstitial cells of Cajal associated with the myenteric plexus (ICC-MP) are pacemaker cells of the small intestine, producing the characteristic omnipresent electrical slow waves, which orchestrate peristaltic motor activity and are associated with rhythmic intracellular calcium oscillations. Our objective was
Life-threatening interaction of mibefradil and beta-blockers with dihydropyridine calcium channel blockers
Mullins M E, et al.
JAMA : The Journal of the American Medical Association, 280(2), 157-158 (1998)
Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neurons
McDonough S I and Bean B P
Molecular Pharmacology, 54(6), 1080-1087 (1998)
Nicholas C K Valerie et al.
Biochemical pharmacology, 85(7), 888-897 (2013-01-05)
Glioblastoma multiforme (GBM) are brain tumors that are exceptionally resistant to both radio- and chemotherapy regimens and novel approaches to treatment are needed. T-type calcium channels are one type of low voltage-gated channel (LVCC) involved in embryonic cell proliferation and
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