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Merck

M5005

Sigma-Aldrich

氯化锰 四水合物

BioReagent, suitable for insect cell culture

别名:

Manganese chloride hydrate, Manganese chloride tetrahydrate, MnCl2.4H2O

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About This Item

线性分子式:
MnCl2 · 4H2O
CAS号:
分子量:
197.91
EC號碼:
MDL號碼:
分類程式碼代碼:
12352207
PubChem物質ID:
NACRES:
NA.28

產品線

BioReagent

化驗

≥99% (by AgNO3, titration)

技術

cell culture | insect: suitable

mp

58 °C (lit.)

SMILES 字串

Cl[Mn]Cl.[H]O[H].[H]O[H].[H]O[H].[H]O[H]

InChI

1S/2ClH.Mn.4H2O/h2*1H;;4*1H2/q;;+2;;;;/p-2

InChI 密鑰

CNFDGXZLMLFIJV-UHFFFAOYSA-L

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應用

四水合氯化锰 (II) 已被用于:
  • 作为真菌完全培养基中的微量元素
  • 作为耳蜗器官型培养的培养基中的补充
  • 测定其对小鼠单纯疱疹病毒-1 (HSV-1)、水泡性口炎病毒 (VSV) 和痘苗病毒的体内抗病毒活性

生化/生理作用

锰是哺乳动物组织中必需的和含量丰富的金属之一。在发育、神经元功能、免疫调节、生殖和抗氧化防御等生理过程中起关键作用。作为辅助因子,调节酶的活性,如氧化还原酶、异构酶、转移酶、连接酶、裂合酶和水解酶,参与固有免疫。

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Eye Dam. 1 - STOT RE 2

標靶器官

Brain

儲存類別代碼

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

水污染物質分類(WGK)

WGK 2

閃點(°F)

does not flash

閃點(°C)

does not flash

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Salidroside protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels and inhibiting Apoptosis
Ding X, et al.
Toxicology Letters, 310, 51-60 (2019)
manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses.
Wang C, et al.
Immunity, 48(4), 675-687 (2018)
Weilong Wang et al.
Toxicology letters, 279, 77-86 (2017-08-06)
Manganese (Mn) is an indispensable cofactor for many enzymes and a basic factor for many reproductive and metabolic pathways. However, exposure to high concentrations of Mn can result in deleterious effects on the central nervous system and peripheral nerves, including
Agrobacterium-mediated transformation of the filamentous fungus Aspergillus awamori.
Michielse CB, et al.
Nature Protocols, 3(10), 1671-1671 (2008)
Xuerui Ding et al.
Toxicology letters, 310, 51-60 (2019-04-17)
Manganese (Mn) is an essential cofactor for many enzymes and thus plays an important role in normal growth and development. However, persistent exposure to high Mn concentrations can result in deleterious effects on not only the central nervous system but

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