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Merck

M4267

Sigma-Aldrich

甲芬那酸

别名:

2-[(2,3-二甲基苯基)氨基] 苯甲酸, N -(2,3-二甲苯基)邻氨基苯甲酸

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About This Item

经验公式(希尔记法):
C15H15NO2
CAS号:
分子量:
241.29
EC號碼:
MDL號碼:
分類程式碼代碼:
12161501
PubChem物質ID:
NACRES:
NA.77

起源

Shionogi

SMILES 字串

Cc1cccc(Nc2ccccc2C(O)=O)c1C

InChI

1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)

InChI 密鑰

HYYBABOKPJLUIN-UHFFFAOYSA-N

基因資訊

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應用

甲芬那酸已被用于:
  • 测试其在转基因斑马鱼细胞系(LiPan)中的肝脏毒性作用
  • 测试其在斑马鱼胚胎/幼体中的神经保护功能
  • 在水凝胶微珠中制备粘膜粘附微粒。

一种 NSAID。避免 MRP 介导的多药耐药。特异性且显著增强了蒽环类药物以及替尼泊苷、VP-16 和长春新碱的细胞毒性。

生化/生理作用

甲芬那酸是一种止痛消炎药。它可作为环氧合酶(COX)的抑制剂。它具有肝毒性,并与肝损伤有关。相反,甲芬那酸通过抑制谷氨酸盐诱导的细胞毒性,在体内缺血性中风模型中引起神经保护作用。由于对前列腺素合成的抑制作用,甲草胺可用于减轻水肿和疼痛。

特點和優勢

该化合物收录于受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢》页面。想要浏览手册的其他页面, 请单击此处
该化合物由 Shionogi 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表,请点击此处
这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析证书(COA)

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Janesh Gupta et al.
The New England journal of medicine, 368(2), 128-137 (2013-01-11)
Menorrhagia is a common problem, yet evidence to inform decisions about therapy is limited. In a pragmatic, multicenter, randomized trial, we compared the levonorgestrel-releasing intrauterine system (levonorgestrel-IUS) with usual medical treatment in women with menorrhagia who presented to their primary
Howard Horng et al.
Chemical research in toxicology, 26(3), 465-476 (2013-02-14)
Mefenamic acid, (MFA), a carboxylic acid-containing nonsteroidal anti-inflammatory drug (NSAID), is metabolized into the chemically reactive conjugates MFA-1-O-acyl-glucuronide (MFA-1-O-G) and MFA-S-acyl-CoA (MFA-CoA), which are both implicated in the formation of MFA-S-acyl-glutathione (MFA-GSH) conjugates, protein-adduct formation, and thus the potential toxicity
S Kasichayanula et al.
Diabetes, obesity & metabolism, 15(3), 280-283 (2012-10-16)
Dapagliflozin is a selective sodium glucose cotransporter 2 (SGLT2) inhibitor that decreases serum glucose by reducing renal glucose reabsorption, thereby promoting urinary glucose excretion. Dapagliflozin is primarily metabolized via the uridine diphosphate-glucuronosyltransferase (UGT)1A9 pathway to its major inactive metabolite, dapagliflozin
Filitsa Dimiza et al.
Dalton transactions (Cambridge, England : 2003), 40(34), 8555-8568 (2011-08-02)
Copper(II) complexes with the non-steroidal antiinflammatory drug mefenamic acid in the presence of aqua or nitrogen donor heterocyclic ligands (2,2'-bipyridine, 1,10-phenanthroline, 2,2'-bipyridylamine or pyridine) have been synthesized and characterized. The crystal structures of [(2,2'-bipyridine)bis(mefenamato)copper(II)], 2, [(2,2'-bipyridylamine)bis(mefenamato)copper(II)], 4, and [bis(pyridine)bis(methanol)bis(mefenamato)copper(II)], 5
Taro Kojima et al.
Pharmaceutical research, 29(10), 2777-2791 (2012-01-06)
The stabilization mechanism of a supersaturated solution of mefenamic acid (MFA) from a solid dispersion with EUDRAGIT(®) EPO (EPO) was investigated. The solid dispersions were prepared by cryogenic grinding method. Powder X-ray diffractometry, in vitro dissolution test, in vivo oral

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