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About This Item
经验公式（希尔记法）:
C20H16N2O6
CAS号:
分子量:
380.35
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
off-white to light tan
溶解度
DMSO: ≥20 mg/mL
儲存溫度
2-8°C
SMILES 字串
Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O
InChI
1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)
InChI 密鑰
MIQUEZGHEJGPJB-UHFFFAOYSA-N
應用
MST-312已被用于利用小鼠成纤维细胞（NIH-3T3）的细胞侵袭检测以及结肠成纤维细胞中的免疫共沉淀实验。
生化／生理作用
MST-312是一种端粒酶抑制剂。端粒是存在于染色体末端的核蛋白复合物，含有会随着每个重复的细胞周期而缩短DNA片段串联重复序列。端粒缩短可引起功能的丧失，从而导致细胞衰老和有限的生存能力。逆转录酶端粒酶在永生化细胞系和大多数癌细胞系中维持着端粒的长度和功能，而端粒酶的活性也与肿瘤的发生有关。端粒延长也被认为是促进iPS细胞基因组稳定性和无限自我更新的重要因素。1 μM MST-312已显示出在U937细胞中能够有效缩短端粒长度并对增殖进行抑制。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Quercetin is a natural flavonoid with well-established anti-proliferative activities against a variety of cancers. Telomerase inhibitor MST-312 also exhibits anti-proliferative effect on various cancer cells independent of its effect on telomere shortening. However, due to their low absorption and toxicity
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