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product name
BRACO19 盐酸盐, ≥96% (HPLC)
化驗
≥96% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
yellow to brown
溶解度
H2O: 5 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
Cl.Cl.Cl.CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc5cc(NC(=O)CCN6CCCC6)ccc25)cc1
InChI
1S/C35H43N7O2.3ClH/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42;;;/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39);3*1H
InChI 密鑰
MJAPNWJRLLDPAB-UHFFFAOYSA-N
應用
BRACO19 盐酸盐已被用于研究 G4 稳定剂在潜伏人类免疫缺陷病毒-1 (HIV-1) 感染的细胞中抗病毒活性的作用。
生化／生理作用
BRACO19 是一种端粒酶抑制剂，可稳定 G-四链体，靶向端粒 G-四链体，诱导 DNA 损伤和细胞周期阻滞。
端粒酶与肿瘤进展相关，在编号肿瘤中高表达。已知 BRACO19 可阻止端粒酶的封端和催化操作，因此，可作为癌症治疗的有效治疗方法。BRACO19 确立了对 HIV（人类免疫缺陷病毒）的抗病毒活性。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19.
Perrone R, et al.
The Journal of Antimicrobial Chemotherapy, 69(12), 3248-3258 (2014)
Deficiency in DNA damage response, a new characteristic of cells infected with latent HIV-1.
Piekna-Przybylska D, et al.
Cell Cycle, 16(10), 968-978 (2017)
Yu-Lun Chen et al.
The Chinese journal of physiology, 59(6), 331-347 (2016-11-07)
Lung resistance-related protein (LRP) is a human major vault protein (MVP) implicated in drug resistance of cancer cells in a cell-type dependent manner. The primary goal of the study was to understand the role(s) of LRP in doxorubicin (DOX) resistance
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.
Burger A M, et al.
Cancer Research, 65(4), 1489-1496 (2005)
Shyam Sushama Jose et al.
Frontiers in genetics, 9, 345-345 (2018-09-14)
Telomeropathies are rare disorders associated with impaired telomere length control mechanisms that frequently result from genetic mutations in the telomerase complex. Dyskeratosis congenita is a congenital progressive telomeropathy in which mutation in the telomerase RNA component (TERC) impairs telomere maintenance
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