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M3315

Sigma-Aldrich

MJ33 锂盐

powder, ≥90% (NMR)

别名:

1-十六烷基-3-（三氟乙基）-sn-甘油-2-磷酸甲醇锂

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About This Item

经验公式（希尔记法）:
C22H43F3O6PLi
CAS号:
199106-13-3
分子量:
498.48
MDL號碼:
MFCD03787978
分類程式碼代碼:
41106300
PubChem物質ID:
24278549
NACRES:
NA.77

品質等級

100

化驗

≥90% (NMR)

形狀

powder

顏色

white to beige

溶解度

H2O: ≥5 mg/mL (warmed at 60 °C)

儲存溫度

2-8°C

SMILES 字串

CCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP(OC)([O-])=O.[Li+]

InChI

1S/C22H44F3O6P.Li/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-29-18-21(31-32(26,27)28-2)19-30-20-22(23,24)25;/h21H,3-20H2,1-2H3,(H,26,27);/q;+1/p-1

InChI 密鑰

GDLMLQJISATCEL-UHFFFAOYSA-M

應用

MJ33锂盐已被用作过氧化物酶VI（Prdx6）抑制剂：
  • 在体外和乳腺癌细胞系（MCF-7）细胞裂解物中研究其特异性Prdx6过氧化物酶活性
  • 以研究其对与高氧暴露相关的急性肺损伤小鼠模型的影响
  • 研究其作为治疗剂的潜在用途

生化／生理作用

MJ33作为激动剂诱导的烟酰胺腺嘌呤二核苷酸磷酸盐（NADPH）氧化酶2型（NOX2）活化的无毒和强效抑制剂。它还可以预防与小鼠肺炎症相关的肺损伤。MJ33是一种氟化脂质类似物，通过模拟底物的过渡态来阻断酶。
磷脂酶A2（PLA2）的新型，活性部位指导，特异性，竞争性和可逆性抑制剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Inhibition of the phospholipase A2 activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia
Benipal B, et al.
Redox Biology, 4, 321-327 (2015)
Fisher, A.B. et al.
American Journal of Physiology. Cell Physiology, 280, 748-748 (2001)
Cristian O'Flaherty et al.
Antioxidants (Basel, Switzerland), 9(1) (2020-01-08)
Peroxiredoxins (PRDXs) are antioxidant enzymes that protect cells from oxidative stress and play a role in reactive oxygen species (ROS)-mediated signaling. We reported that PRDXs are critical for human fertility by maintaining sperm viability and regulating ROS levels during capacitation.
José Pablo Vázquez-Medina et al.
American journal of physiology. Lung cellular and molecular physiology, 316(4), L656-L668 (2019-02-01)
Peroxiredoxin 6 (Prdx6) is a multifunctional enzyme that serves important antioxidant roles by scavenging hydroperoxides and reducing peroxidized cell membranes. Prdx6 also plays a key role in cell signaling by activating the NADPH oxidase, type 2 (Nox2) through its acidic
J W Chen et al.
The Journal of biological chemistry, 275(37), 28421-28427 (2000-07-14)
This report provides definitive evidence that the protein 1-Cys peroxiredoxin is a bifunctional ("moonlighting") enzyme with two distinct active sites. We have previously shown that human, rat, and bovine lungs contain an acidic Ca(2+)-independent phospholipase A(2) (aiPLA(2)). The cDNA encoding

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