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L6895

Sigma-Aldrich

单磷酰脂质A 来源于肠沙门氏菌 明尼苏达血清型 Re 595(Re 突变体)

lyophilized powder, TLR ligand tested

别名:

来自沙门氏菌的单磷酰脂质A

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About This Item

MDL號碼:
分類程式碼代碼:
12352211
NACRES:
NA.25

生物源

Salmonella enterica (serotype minnesota Re 595 Re mutant)

品質等級

形狀

lyophilized powder

雜質

<0.2% Ketodeoxyoctonate (KDO)

運輸包裝

ambient

儲存溫度

2-8°C

應用

脂质A分子组成脂质膜,锚定革兰氏阴性细菌产生的内毒素的核心组分。 脂质A分子可诱导免疫反应。 在结构上,脂质A分子由两个葡萄糖胺单元组成,两者具有不同的物种依赖性脂肪酰链数、同一性和磷酸化程度。
来自肠道沙门氏菌血清型明尼苏达Re 595的单磷酰脂质A可用于比较评估不同LPA分子和类似物中特定结构的抗原性。

生化/生理作用

脂多糖(LPS)是革兰氏阴性细菌细胞壁的特征成分。LPS及其脂质A部分通过Toll样受体4(TLR4)刺激先天免疫系统的细胞,TLR4是Toll样受体蛋白家族的成员,该家族可识别常见的病原体相关分子模式(PAMP)。
脂质A具有免疫刺激佐剂活性,包括巨噬细胞、T细胞和B细胞活化。 研究表明,脂质A对Th2的刺激性比对Th1的大。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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