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Merck

L5420

Sigma-Aldrich

Lumefantrine

别名:

(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol, Benflumetol, CPG-56695

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About This Item

经验公式(希尔记法):
C30H32Cl3NO
CAS号:
分子量:
528.94
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

yellow

溶解度

DMSO: 2 mg/mL, clear (warmed)

起源

Novartis

儲存溫度

room temp

SMILES 字串

CCCCN(CCCC)CC(O)c1cc(Cl)cc2C(=C/c3ccc(Cl)cc3)\c4cc(Cl)ccc4-c12

InChI

1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-

InChI 密鑰

DYLGFOYVTXJFJP-MYYYXRDXSA-N

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一般說明

Lumefantrine, also known as benflumetol is an aryl-amino alcohol. It is a member of the group of arylamine alcohols like quinine, mefloquine and halofantrine.

應用

Lumefantrine has been used:
to study its effect on ex-vivo Plasmodium falciparum sensitivity using the tritiated hypoxanthine-based assay
as a standard in the quantification of combined tablet formulation using HPTLC
as a drug molecule in in vitro growth inhibition assay for in vitro B. caballi growth inhibition studies

生化/生理作用

Lumefantrine is is an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.

特點和優勢

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

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Thomas T Thomsen et al.
The American journal of tropical medicine and hygiene, 85(6), 979-983 (2011-12-07)
Tanzania implemented artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in November of 2006 because of resistance to sulfadoxine-pyrimethamine. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance, which initially may be detected at
Reduced ex vivo susceptibility of Plasmodium falciparum after oral artemether-lumefantrine treatment in Mali
Dama S, et al.
Malaria Journal, 16(1), 59-59 (2017)
Lumefantrine and o-choline-Parasite metabolism specific drug molecules inhibited in vitro growth of Theileria equi and Babesia caballi in MASP culture system
Maji C, et al.
Ticks and Tick-Borne Diseases, 10(3), 568-574 (2019)
Use of a model procedure for transfer of Minilab qualitative screening TLC methods for lumefantrine and artemether in a combined tablet formulation to individual and simultaneous quantitative HPTLC-densitometry methods
Nguyen M and Sherma J
Malaria Journal (2013)
Anti-infective agents
Drugs During Pregnancy and Lactation, 115-176 (2015)

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