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Merck

361593

Sigma-Aldrich

青蒿素

98%

别名:

青蒿素

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About This Item

经验公式(希尔记法):
C15H22O5
CAS号:
分子量:
282.33
MDL號碼:
分類程式碼代碼:
12352205
PubChem物質ID:
NACRES:
NA.79

化驗

98%

形狀

solid

光學活性

[α]20/D +76°, c = 0.5 in methanol

mp

156-157 °C (lit.)

抗生素活性譜

parasites
viruses

應用

metabolomics
vitamins, nutraceuticals, and natural products

作用方式

enzyme | inhibits

SMILES 字串

C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3OC4(C)CC[C@@H]1[C@@]23OO4

InChI

1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1

InChI 密鑰

BLUAFEHZUWYNDE-NNWCWBAJSA-N

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一般說明

青蒿素是从青蒿(Artemisia annua)中提取得到的。它具有抗癌、 抗原虫和抗病毒活性。青蒿素与脑干脑病有关。

應用

青蒿素已可用于:
  • 药物敏感性测定
  • 作为对毛状根所含青蒿素进行定量的标准品
  • 通过3-(4,5-二甲基-2-噻唑)-2,5-二苯基溴化四氮唑(MTT)测定来检测细胞活力
  • 作为抗疟药,用于研究自噬相关(ATG)基因在恶性疟原虫( P. falciparum )无性和有性血液期的作用

生化/生理作用

青蒿素是一种倍半萜内酯,是一种高效的抗疟疾(恶性疟疾)药物。青蒿素也是一种能有效对抗血吸虫病的驱虫剂(寄生虫)。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Jürg Utzinger et al.
Current opinion in investigational drugs (London, England : 2000), 8(2), 105-116 (2007-03-03)
Schistosomiasis is a significant health issue caused by a blood fluke that affects more than 200 million individuals worldwide, over half of whom suffer from disease-associated symptoms. In areas of high burden, disease is mainly managed by controlling morbidity with
Antiprotozoal drugs
Simooya OO
Side Effects of Drugs Annual, 30, 336-342 (2008)
Deciphering genetic regulation of CD14 by SP1 through characterization of peripheral blood mononuclear transcriptome of P. faiciparum and P. vivax infected malaria patients
Chakraborty B, et al.
EBioMedicine, 37, 442-452 (2018)
Rita Piedade et al.
Expert opinion on drug metabolism & toxicology, 7(10), 1185-1200 (2011-09-09)
Plasmodium falciparum malaria is one of the world's most lethal infectious diseases, commanding millions of drug administrations per year. The pharmacogenetics of these drugs is poorly known, although its application can be pivotal for the optimized management of this disease.
Stimulation of artemisinin synthesis by combined cerebroside and nitric oxide elicitation in Artemisia annua hairy roots
Wang JW, et al.
Applied Microbiology and Biotechnology, 85(2), 285-292 (2009)

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