生物源
bovine milk
形狀
ammonium sulfate suspension
比活性
≥2,000 units/mg protein (BCA)
儲存溫度
2-8°C
一般說明
牛乳脂蛋白脂酶(LPL)是一种糖蛋白。它以同型二聚体形式存在，由两个N-连接的寡糖组成。具有热不稳定性。
應用
牛乳脂蛋白脂酶已用于：
- 研究脂蛋白脂酶作为补充剂对乳腺癌细胞MDA-MB-231中DiI(1,1′-双十八烷基-3,3,3′-四甲基吲哚碳菁高氯酸盐)-极低密度脂蛋白(VLDL)摄取的影响
- 处理人脑微血管内皮细胞(HBMEC)以脂解富含三酰甘油的脂蛋白(TGRL)
- 检测脂蛋白脂酶对正常人星形胶质细胞基因表达的影响
生化／生理作用
牛乳脂蛋白脂酶(LPL)具有最高的脂解活性。它与酪蛋白胶束有关。LPL调节甘油三酯利用度，具有位点特异性。脂酶通常催化甘油三酯的脂裂解，尤其是甘油三酯sn-1和sn-3位的脂肪酸。
單位定義
以 p -硝基苯丁酸酯为底物，在 37°C、pH 7.2 条件下，1 个单位每分钟将释放 1.0 nmol p -硝基苯酚。
外觀
用 3.8 M 硫酸铵、0.02 MTris HCl (pH 8.0) 混悬
準備報告
亲和纯化
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Richard E Morton et al.
Journal of lipid research, 63(2), 100166-100166 (2022-01-13)
Apolipoprotein F (ApoF) modulates lipoprotein metabolism by selectively inhibiting cholesteryl ester transfer protein activity on LDL. This ApoF activity requires that it is bound to LDL. How hyperlipidemia alters total plasma ApoF and its binding to LDL are poorly understood.
Leslie E Lupien et al.
Journal of lipid research, 61(2), 205-218 (2019-12-07)
We previously described the expression of CD36 and LPL by breast cancer (BC) cells and tissues and the growth-promoting effect of VLDL observed only in the presence of LPL. We now report a model in which LPL is bound to
Dean Oldham et al.
Frontiers in cardiovascular medicine, 9, 926631-926631 (2022-08-02)
Lipoprotein lipase (LPL) plays a crucial role in preventing dyslipidemia by hydrolyzing triglycerides (TGs) in packaged lipoproteins. Since hypertriglyceridemia (HTG) is a major risk factor for cardiovascular disease (CVD), the leading cause of death worldwide, methods that accurately quantify the
Shin-Ichi Yokota et al.
Infection and immunity, 78(1), 468-476 (2009-10-28)
Helicobacter pylori is recognized as an etiological agent of gastroduodenal diseases. H. pylori produces various toxic substances, including lipopolysaccharide (LPS). However, H. pylori LPS exhibits extremely weakly endotoxic activity compared to the typical LPS, such as that produced by Escherichia
Silvia Hilt et al.
Frontiers in chemistry, 10, 896386-896386 (2022-06-21)
Several neurodegenerative diseases are driven by misfolded proteins that assemble into soluble aggregates. These "toxic oligomers" have been associated with a plethora of cellular dysfunction and dysregulation, however the structural features underlying their toxicity are poorly understood. A major impediment
商品
The potential for the prevention and treatment of cardiovascular disease through increased dietary intake of omega-3 (w-3) fish oils is not a recent scientific discovery.
Lipid Induced Insulin Resistance
Instructions for working with enzymes supplied as ammonium sulfate suspensions
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