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Merck

L0521

Sigma-Aldrich

脂蛋白A4

ethanol solution

别名:

(5S,6R,15S)-三羟基-(7E,9E,11Z,13E)-二十碳四烯酸

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About This Item

经验公式(希尔记法):
C20H32O5
CAS号:
分子量:
352.47
EC號碼:
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.77

形狀

ethanol solution

品質等級

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O

InChI

1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1

InChI 密鑰

IXAQOQZEOGMIQS-SSQFXEBMSA-N

生化/生理作用

脂蛋白A4(LXA4)由花生四烯酸合成,是一种内源性脂氧合酶衍生的类花生酸介体。它是一种有效的人蛋白激酶C激活剂。它抑制自然杀伤细胞的细胞毒性。LXA4调节免疫系统和炎症。在大脑中,它调节神经元信号传导和慢波睡眠。LXA4与大麻素受体结合。LXA4在子宫内膜和生殖功能的维持中起关键作用。LXA4的消耗有助于囊性纤维化(CF)的病理生理。

包裝

氩气包装。

象形圖

FlameExclamation mark

訊號詞

Danger

危險聲明

危險分類

Eye Irrit. 2 - Flam. Liq. 2

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

55.4 °F

閃點(°C)

13 °C

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


分析证书(COA)

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访问文档库

Physiological impact of abnormal lipoxin A4 production on cystic fibrosis airway epithelium and therapeutic potential.
Higgins G, et al.
BioMed Research International, 2015(3), 439-439 (2015)
Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor.
Pamplona FA, et al.
Proceedings of the National Academy of Sciences of the USA, 109(51), 21134-21139 (2012)
Stephanie G Dakin et al.
Scientific reports, 7(1), 11009-11009 (2017-09-10)
The mechanisms underpinning the failure of inflammation to resolve in diseased musculoskeletal soft tissues are unknown. Herein, we studied bioactive lipid mediator (LM) profiles of tendon-derived stromal cells isolated from healthy donors and patients with chronic tendinopathy. Interleukin(IL)-1β treatment markedly
The role of lipoxin A 4 in endometrial biology and endometriosis.
Canny GO and Lessey BA
Mucosal Immunology, 6(3), 439-439 (2013)
The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo.
Chiang N, et al.
Pharmacological Reviews, 58(3), 463-487 (2006)

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