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Merck
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主要文件

F0504

Sigma-Aldrich

Folate binding protein from bovine milk

lyophilized powder

别名:

Folate Protein

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About This Item

MDL號碼:
MFCD00131098
分類程式碼代碼:
12352202
NACRES:
NA.61

生物源

bovine milk

形狀

lyophilized powder

用途

 mg sufficient for ~4,000 assays

成份

Protein, 20-40% modified Warburg-Christian

技術

ligand binding assay: suitable
surface plasmon resonance (SPR): suitable

容量

1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.)

儲存溫度

−20°C

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應用

Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers.
Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance and in the uptake studies in kidney proximal tubule cells.
Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues.

生化／生理作用

Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio. It is involved in the transport of folate and improves their bioavailability.

包裝

Package size based on protein content

品質

Purified over 1,000 fold. May contain a trace of β-mercaptoethanol.

外觀

Lyophilized powder containing buffer salt as sodium citrate

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
051M7670V
051M7678
051M7677
051M7676
051M7675

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Dietary interactions influence the effects of bovine folate-binding protein on the bioavailability of tetrahydrofolates in rats
Jones ML, et al.
The Journal of Nutrition, 133(2), 489-495 (2003)
Radioisotopic assay for measurement of serum folate levels.
S Waxman et al.
Blood, 38(2), 219-228 (1971-08-01)
Radioassay of serum folate.
R T Dunn et al.
Clinical chemistry, 19(10), 1101-1105 (1973-10-01)
Martin D Forster et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 71(11), 945-950 (2007-08-23)
The alpha-folate receptor (alpha-FR) is a folate transporter with restricted expression levels in normal tissues. It is over-expressed in several cancers, particularly epithelial carcinomas, including nonmucinous ovarian carcinoma. It offers a novel therapeutic target for selective imaging and cytotoxic agents.
LRP2 mediates folate uptake in the developing neural tube
Kur E, et al.
Journal of Cell Science, jcs-140145 (2014)
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