K4643

PKCθ, active, GST tagged human

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• 别名: MGC126514, MGC141919, PRKCQ, PRKCT, nPKC-theta
• 分類程式碼代碼: 12352200
• NACRES: NA.32

属性

• 重組細胞: expressed in baculovirus infected Sf9 cells
• 品質等級: 200
• 產品線: PRECISIO^® Kinase
• 化驗: ≥70% (SDS-PAGE)
• 形狀: buffered aqueous glycerol solution
• 比活性: 673-911 nmol/min·mg
• 分子量: ~110 kDa
• UniProt登錄號: Q04759
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... PRKCQ(5588)

说明

一般說明

PKCθ (protein kinase C θ) is a serine/threonine kinase, belonging to protein kinase C family.

生化／生理作用

PKCθ (protein kinase C θ) is required for T cell activation and proliferation. In presence of TCR (T cell receptor) stimulation, it is responsible for activation of NF-AT (nuclear factor of activated T-cells), NF-κB (nuclear factor κ B) and AP1 (adaptor-related protein complex 1). It might be a target for the treatment of type 2 diabetes. PKCθ is needed for fat-mediated insulin resistance in skeletal muscle.

外觀

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

法律資訊

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)