K2644

Kisspeptin-234 trifluoroacetate salt

≥95% (HPLC)

• 别名: kisspeptin-10 peptide 234
• 经验公式（希尔记法）: C₆₃H₇₈N₁₈O₁₃ · xC₂HF₃O₂
• CAS号: 1848962-29-7
• 分子量: 1295.41 (free base basis)
• 分類程式碼代碼: 12352200
• NACRES: NA.32

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: film
• 顏色: colorless to white
• 溶解度: H₂O: >1 mg/mL
• 儲存溫度: −20°C

说明

生化／生理作用

Kisspeptin-234 is a 10-amino acid peptide antagonist with potent neutral antagonist activity at GPR-54 and competes directly at the Kisspeptin-10 binding site. Kisspeptin-234 is the first reported antagonist for the kisspeptin-1/GPR-54 signaling system.

Gonadotropin-releasing hormone (GnRH) modulates the hypothalamic-pituitary-gonadal axis, enabling the brain to control reproductive processes. Kisspeptin-1 is a peptide neurotransmitter released from afferent neurons onto GnRH neurons, where it binds to and activates to the orphan receptor GPR-54 to regulate release of GnRH. Regulation of kisspeptin/GPR-54 signaling presents an opportunity for reproductive therapeutics above the level of GnRH and gonadotropin secretion. Pharmacological and selective tools are needed to better understand kisspeptin-1/GPR-54 signaling. Analogs of kisspeptin-10, a 10-amino acid portion of kisspeptin-1, were designed to be full and neutral antagonists of GPR-54.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable