跳转至内容
Merck

I2142

Sigma-Aldrich

KN-62

≥95%, powder

别名:

(S)-5-异喹啉磺酸 4-[(2S)-2-[(5-异喹啉磺酰基)甲氨基]-3-氧代-3-(4-苯基-1-哌嗪基)丙基]苯酯, 1-[N,O-二(5-异喹啉磺酰基)-N-甲基-L-型酪氨酸]-4-苯基哌嗪

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C38H35N5O6S2
分子量:
721.84
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic (organic)

化驗

≥95%

形狀

powder

顏色

yellow

mp

130 °C

溶解度

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
methanol: 10 mg/mL
DMSO: 12 mg/mL
chloroform: 20 mg/mL

儲存溫度

−20°C

SMILES 字串

O=S(OC1=CC=C(C[C@@H](C(N2CCN(C3=CC=CC=C3)CC2)=O)N(C)S(C4=CC=CC5=C4C=CN=C5)(=O)=O)C=C1)(C6=CC=CC7=C6C=CN=C7)=O

InChI

1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1

InChI 密鑰

RJVLFQBBRSMWHX-DHUJRADRSA-N

基因資訊

human ... P2RX7(5027)

正在寻找类似产品? 访问 产品对比指南

生化/生理作用

选择性抑制大鼠脑 Ca2+/钙调蛋白依赖性蛋白激酶 II。

特點和優勢

《受体分类和信号转导手册》的 Ca/CaMKsP2受体:P2X离子通道家族 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Safina Gadeock et al.
Biochimica et biophysica acta, 1798(11), 2058-2066 (2010-07-31)
The P2X7 receptor is an extracellular ATP-gated cation channel critical in inflammation and immunity, and can be up-regulated by IFN-γ and LPS. This study aimed to examine the effect of TGF-β1 on the up-regulation of P2X7 function and expression in
Antagonists of the P2X(7) receptor. From lead identification to drug development.
Simon D Guile et al.
Journal of medicinal chemistry, 52(10), 3123-3141 (2009-02-05)
Nikki Jo-Hao Weng et al.
Stem cell research, 23, 39-49 (2017-07-04)
New methods are needed to reduce dynamic blebbing which inhibits cell attachment and survival during passaging of pluripotent stem cells. We tested the hypothesis that activation of the P2X7 receptor by extracellular ATP during passaging initiates dynamic blebbing. The P2X7
Regina Stark et al.
Science immunology, 3(30) (2018-12-16)
Tissue-resident memory T cells (TRM) are noncirculating immune cells that contribute to the first line of local defense against reinfections. Their location at hotspots of pathogen encounter frequently exposes TRM to tissue damage. This history of danger-signal exposure is an
R J MacLeod et al.
The Journal of membrane biology, 172(1), 59-66 (1999-11-07)
To assess the activation of the charybdotoxin-insensitive K(+) channel responsible for Regulatory Volume Decrease (RVD) after substantial volume increases, we measured intracellular pH (pH(i)), intracellular calcium ([Ca(2+)](i)) and inhibitors of kinases and phosphoprotein phosphatases in guinea pig jejunal villus enterocytes

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门