一般說明
血红素结合蛋白（HPX）由中央神经紧张的系统的细胞产生。它是一种60 kDa的血清糖蛋白。
應用
来自人血浆的血红素结合蛋白已经使用金黄色葡萄球菌表面定植测定。它也已被用于刺激混合淋巴细胞，以确定急性排斥反应中的生物标志物。
生化／生理作用
血红素结合蛋白是一种急性期蛋白，通过其血红素清除活性对氧化强制降解起主要保护作用。血红蛋白以高亲和力结合血红素，对于回收与血红素分子结合的铁以及防止血红素诱导的细胞损伤至关重要。 游离血红素从血红蛋白等蛋白质中释放或丢失后，可以催化活性氧的形成。 血红素是亲脂性的，并相互螯合到脂质膜中，并参与高毒性羟基自由基的形成。 血红素结合蛋白还可以防止血红素介导的LDL胆固醇氧化。
血红素结合蛋白还可以通过活化巨噬细胞对IL-6和TNF-α分泌的负调节来发挥抗炎作用。
血红素结合蛋白还可以通过活化巨噬细胞对IL-6和TNF-α分泌的负调节来发挥抗炎作用。
外觀
含有钠磷酸盐、NaCl和KCl、pH值7.4的冻干粉
免責聲明
仅供研究使用。本品在法国的科研应用受到监管，包括用于进口和出口活动（法国《公共卫生法典》Public Health Code Article L 1211-1 paragraph 2）。如《公共卫生法典》所述，购买者（即最终用户）需要从法国研究部(France Ministry of Research)获得进口授权。订购此产品即代表您已确认获得合法的进口授权。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Francesca Vinchi et al.
Circulation, 127(12), 1317-1329 (2013-03-01)
Hemolytic diseases are characterized by enhanced intravascular hemolysis resulting in heme-catalyzed reactive oxygen species generation, which leads to endothelial dysfunction and oxidative damage. Hemopexin (Hx) is a plasma heme scavenger able to prevent endothelial damage and tissue congestion in a
Yu-Hong Shi et al.
Dong wu xue yan jiu = Zoological research, 33(5), 481-486 (2012-09-29)
The warm temperature acclimation related 65 kDa protein-2 (Wap65-2), a teleost plasma glycoprotein, plays an important role in immune regulation against bacterial infection. Here, for the first time we determined the full length cDNA sequence of the Japanese sea bass
Zhengyang Wang et al.
Biochimica et biophysica acta, 1824(4), 692-700 (2012-02-14)
The pleural effusion proteome has been found containing information that directly reflects pathophysiological status and represents a potential diagnostic value for pulmonary diseases. However, the variability in protein composition between malignant and benign effusions is not well understood. Herein, we
Paolo Ascenzi et al.
Biochemical and biophysical research communications, 428(2), 239-244 (2012-10-17)
Hemopexin (HPX) displays a pivotal role in heme scavenging and delivery to the liver. In turn, heme-Fe-hemopexin (HPX-heme-Fe) displays heme-based spectroscopic and reactivity properties. Here, kinetics and thermodynamics of cyanide binding to ferric and ferrous hexa-coordinate human plasma HPX-heme-Fe (HHPX-heme-Fe(III)
Tirthartha Chattopadhyay et al.
Biochemical and biophysical research communications, 420(4), 862-868 (2012-04-03)
Proteins containing hemopexin fold domain are suggested to have diverse functions in various living organisms. In order to investigate the structure and function of this type of protein in rice plant (Oryza sativa), the gene encoding a hemopexin fold protein
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