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Merck

MAK316

Sigma-Aldrich

亚铁血红素检测试剂盒

sufficient for 250 colorimetric tests

别名:

Heme Quantification Kit

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About This Item

分類程式碼代碼:
12161503
NACRES:
NA.84

檢測方法

colorimetric

相關疾病

hematological disorder

儲存溫度

2-8°C

一般說明

血红素是卟啉家族的一员。在线粒体和细胞质中合成,是血红蛋白、细胞色素、过氧化氢酶和过氧化物酶等多种必需蛋白质的关键辅基。游离血红素在溶血后可从血红蛋白中释放,具有促炎作用,并促进铁衍生的活性氧。血红素测定被各种血液病研究者广泛实践。

特點和優勢

与高通量处理系统兼容。

適合性

适用于血液、血浆、血清、尿液、携带酶的血红素等多种生物样品中血红素的定量测定及药物对血红素代谢影响的评价。

原則

血红素含量测定基于碱性水溶液法,其中血红素转化为均匀的有色形式,产生比色 (400 nm) 结果,与样品中的血红素浓度成正比。优化后的配方减少了干扰,表现出较高的灵敏度。1 mg/dL 血红素等于 15.3M、0.001% 或 10ppm。该试剂盒 96 孔格式的线性检测范围为 0.6-125M 血红素。

象形圖

CorrosionEnvironment

訊號詞

Warning

危險聲明

危險分類

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Met. Corr. 1

儲存類別代碼

8B - Non-combustible corrosive hazardous materials

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.
Vinchi F, et al.
Blood, 127(4), 473-486 (2016)
Role of heme and heme-proteins in trypanosomatid essential metabolic pathways.
Tripodi K E, et al.
Enzyme Research, 2011 (2011)
Alfonso Rubio-Navarro et al.
Frontiers in pharmacology, 10, 740-740 (2019-07-25)
Massive intravascular hemolysis is associated with acute kidney injury (AKI). Nuclear factor erythroid-2-related factor 2 (Nrf2) plays a central role in the defense against oxidative stress by activating the expression of antioxidant proteins. We investigated the role of Nrf2 in
George T Mukosera et al.
Nitric oxide : biology and chemistry, 79, 57-67 (2018-07-31)
Dinitrosyl iron complexes (DNICs) are important intermediates in the metabolism of nitric oxide (NO). They have been considered to be NO storage adducts able to release NO, scavengers of excess NO during inflammatory hypotensive shock, and mediators of apoptosis in
Beatriz Alvarez-Castelao et al.
eLife, 9 (2020-04-25)
We examined the feedback between the major protein degradation pathway, the ubiquitin-proteasome system (UPS), and protein synthesis in rat and mouse neurons. When protein degradation was inhibited, we observed a coordinate dramatic reduction in nascent protein synthesis in neuronal cell

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