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Merck

H4415

Sigma-Aldrich

HC-030031

≥98% (HPLC), powder

别名:

1,2,3,6-四氢-1,3-二甲基-N- [4-(1-甲基乙基)苯基]-2,6-二氧代-7H-嘌呤-7-乙酰胺, 2-(1,3-二甲基-2,6-二氧代-1,2,3,6-四氢-7H-嘌呤-7-基)-N-(4-异丙基苯基)乙酰胺

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About This Item

经验公式(希尔记法):
C18H21N5O3
分子量:
355.39
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.25

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 10 mg/mL, clear

儲存溫度

room temp

SMILES 字串

CC(C)c1ccc(NC(=O)Cn2cnc3N(C)C(=O)N(C)C(=O)c23)cc1

InChI

1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)

InChI 密鑰

HEQDZPHDVAOBLN-UHFFFAOYSA-N

生化/生理作用

HC-030031是一种选择性TRPA1通道阻滞剂。HC-030031可拮抗福尔马林诱发的钙内流。IC50为5 μM。
HC-030031是一种选择性TRPA1通道阻滞剂。HC-030031可拮抗福尔马林诱发的钙内流以及福尔马林诱导的疼痛。IC50为5 μM。TRPA1拮抗作用是慢性炎症或神经源性疼痛的一种潜在治疗靶标。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Luana Fischer et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 66(4), 311-322 (2016-12-03)
Although TRPA1, SP, histamine and 5-hydroxytryptamine (5-HT) have recognized contribution to nociceptive mechanisms, little is known about how they interact with each other to mediate inflammatory pain in vivo. In this study we evaluated whether TRPA1, SP, histamine and 5-HT
Yan Xu et al.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 29(6), 692-700 (2018-11-02)
Transient receptor potential ankyrin 1 (TRPA1) and substance P (SP), both expression in sensory neurons, have important roles in stress-induced duodenal lesions. The possible contribution of TRPA1 and SP to stress-induced duodenal lesions was explored by using the water immersion
Anthony Bosson et al.
Molecular neurodegeneration, 12(1), 53-53 (2017-07-08)
Excessive synaptic loss is thought to be one of the earliest events in Alzheimer's disease (AD). However, the key mechanisms that maintain plasticity of synapses during adulthood or initiate synapse dysfunction in AD remain unknown. Recent studies suggest that astrocytes
Éva Borbély et al.
Frontiers in pharmacology, 11, 594479-594479 (2021-02-02)
The tachykinin hemokinin-1 (HK-1) is involved in immune cell development and inflammation, but little is known about its function in pain. It acts through the NK1 tachykinin receptor, but several effects are mediated by a yet unidentified target. Therefore, we
Yu-Wei Wu et al.
Glia, 67(2), 246-262 (2018-12-20)
Astrocytes express a complex repertoire of intracellular Ca2+ transients (events) that represent a major form of signaling within individual cells and in astrocytic syncytium. These events have different spatiotemporal profiles, which are modulated by neuronal activity. Spontaneous Ca2+ events appear

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