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product name
羟氯喹 硫酸酯, ≥98% (HPLC), powder
品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
protect from light
顏色
white to off-white
溶解度
H2O: >20 mg/mL
SMILES 字串
OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI
1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChI 密鑰
JCBIVZZPXRZKTI-UHFFFAOYSA-N
基因資訊
human ... TLR7(51284) , TLR9(54106)
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應用
硫酸羟氯喹已:
- 用作自噬的抑制剂,以处理细胞进行凋亡测定用于研究吡柔比星在膀胱癌细胞系中诱导自噬的作用
- 用于通过免疫荧光测定来评估羟氯喹对登革病毒-2 (DENV-2)感染的抗病毒机制
- 用于抑制溶酶体与自噬体的融合
生化/生理作用
硫酸羟氯喹是一种抗炎(通过肿瘤坏死因子)、疾病调节抗风湿药物(DMARD)和血红素聚合酶抑制剂。 它可用于治疗疟疾。
羟氯喹也用于治疗类风湿性关节炎和系统性红斑狼疮。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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