跳转至内容
Merck
所有图片(4)

主要文件

查看所有文档

G0668

Sigma-Aldrich

GW2974

≥98% (HPLC), solid

别名:

N4-(1-Benzyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido­[3,4-d]­pyrimidine-4,6-diamine

登录查看公司和协议定价
所有图片(4)

About This Item

经验公式（希尔记法）:
C23H21N7
CAS号:
202272-68-2
分子量:
395.46
MDL號碼:
MFCD04974495
分類程式碼代碼:
51111800
PubChem物質ID:
24278451
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

顏色

yellow

溶解度

DMSO: ≥20 mg/mL

起源

GlaxoSmithKline

SMILES 字串

CN(C)c1cc2c(Nc3ccc4n(Cc5ccccc5)ncc4c3)ncnc2cn1

InChI

1S/C23H21N7/c1-29(2)22-11-19-20(13-24-22)25-15-26-23(19)28-18-8-9-21-17(10-18)12-27-30(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28)

InChI 密鑰

DYYZXRCFCVDSKD-UHFFFAOYSA-N

基因資訊

human ... EGFR(1956) , ERBB2(2064)

生化／生理作用

Potent and selective dual inhibitor of EGFR (IC50 = 0.016 mM) and ErbB-2 receptor tyrosine kinase.

特點和優勢

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律資訊

Sold for research purposes under agreement from Glaxo­Smith­Kline

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

S Agarwal et al.
British journal of cancer, 100(6), 941-949 (2009-02-26)
There is a pressing need to identify new drug targets and novel approaches for treatment of non-small-cell lung carcinoma (NSCLC). Members of the epidermal growth factor receptor (EGFR) and Met receptor families have been identified as important molecular targets for
Keli Kolegraff et al.
Molecular biology of the cell, 22(8), 1121-1134 (2011-02-18)
Desmocollin-2 (Dsc2) and desmoglein-2 (Dsg2) are transmembrane cell adhesion proteins of desmosomes. Reduced expression of Dsc2 has been reported in colorectal carcinomas, suggesting that Dsc2 may play a role in the development and/or progression of colorectal cancer. However, no studies
Hauke Busch et al.
Molecular systems biology, 4, 199-199 (2008-07-03)
Translation of large-scale data into a coherent model that allows one to simulate, predict and control cellular behavior is far from being resolved. Assuming that long-term cellular behavior is reflected in the gene expression kinetics, we infer a dynamic gene

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门