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品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
white
溶解度
DMSO: >20 mg/mL
H2O: >20 mg/mL
SMILES 字串
Cl.COc1ccc(CCCOC(Cn2ccnc2)c3ccc(OC)cc3)cc1
InChI
1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H
InChI 密鑰
FWLPKVQUECFKSW-UHFFFAOYSA-N
應用
SKF-96365已用作:
- 人类足细胞中的非选择性瞬时受体电位6 (TRPC6)阻滞剂
- 神经元中的库操纵性Ca2+内流拮抗剂
- 小鼠中的瞬时受体电位3 (TRPC3)阻滞剂
生化/生理作用
带烷基化咪唑环的SKF-96365是受体介导的Ca2+内流和电压门控Ca2+内流的选择性抑制剂。SKF-96365介导平滑肌膜的去极化,对乙酰胆碱(ACh)诱导去极化无影响。它是一种SOCE(库操纵性钙内流)阻滞剂。也可抑制Homer1蛋白质表达。SKF-96365在1-甲基-4-苯基吡啶基(MPP)介导的细胞毒性中可诱发保护功能。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
BMC cancer, 8, 125-125 (2008-05-03)
TRP channels have been shown to be involved in tumour generation and malignant growth. However, the expression of these channels in breast cancer remains unclear. Here we studied the expression and function of endogenous TRPC6 channels in a breast cancer
The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels
British Journal of Pharmacology, 160(6), 1464-1475 (2010)
Protective effects of SKF-96365, a non-specific inhibitor of SOCE, against MPP+-induced cytotoxicity in PC12 cells: potential role of Homer1
PLoS ONE, 8(1), e55601-e55601 (2013)
The Biochemical journal, 271(2), 515-522 (1990-10-15)
A novel inhibitor of receptor-mediated calcium entry (RMCE) is described. SK&F 96365 (1-(beta-[3-(4-methoxy-phenyl)propoxy]-4-methoxyphenethyl)-1H- imidazole hydrochloride) is structurally distinct from the known 'calcium antagonists' and shows selectivity in blocking RMCE compared with receptor-mediated internal Ca2+ release. Human platelets, neutrophils and endothelial
Effects of inhibitors of nonselective cation channels on the acetylcholine-induced depolarization of circular smooth muscle from the guinea-pig stomach antrum
Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi, 41(6), 313-327 (2005)
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