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S101

Sigma-Aldrich

(R)-(+)-SKF-38393 盐酸盐

≥98% (HPLC), solid

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About This Item

经验公式（希尔记法）:
C16H17NO2 · HCl
CAS号:
81702-42-3
分子量:
291.77
MDL號碼:
MFCD00055189
分類程式碼代碼:
12352200
PubChem物質ID:
329824192
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

光學活性

[α]22/D +16.1°, c = 1.2 in methanol(lit.)

儲存條件

desiccated

顏色

off-white to light tan

溶解度

0.1 M HCl: 1.2 mg/mL
ethanol: 3.4 mg/mL
H2O: 5 mg/mL
aqueous base: unstable

SMILES 字串

Cl.Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O

InChI

1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1

InChI 密鑰

YEWHJCLOUYPAOH-PFEQFJNWSA-N

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應用

(R)-(+)-SKF-38393盐酸盐已用作D1多巴胺受体激动剂，研究其对1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导帕金森病猕猴睡眠模式的影响。

生化／生理作用

(R)-(+)-SKF-38393盐酸盐是一种D1多巴胺受体激动剂和(±)-SKF-38393的活性对映异构体。它可增强海马体神经元中百日咳毒素不敏感性和蛋白激酶A介导谷氨酸释放。SKF-38393是一种苯并氮杂卓衍生物，具有降低食欲的作用。

特點和優勢

《受体分类和信号转导》手册的多巴胺受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

注意

光敏感

重構

溶液可在4°C条件下储存数日。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
106M4624V
020M4602V
020M46021
020M4602
048K46173

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Both excessive daytime sleepiness (EDS) and rapid eye movement (REM) sleep deregulation are part of Parkinson's disease (PD) non-motor symptoms and may complicate dopamine replacement therapy. We report here that dopamine agonists act differentially on sleep architecture in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Steven J Cooper et al.
European journal of pharmacology, 532(3), 253-257 (2006-02-16)
Free-feeding rats meet much of their daily energy requirements by consuming food in meals during the nocturnal phase of the night/day cycle. Meal pattern analysis methodology has been developed to record the patterns of meal taken over a 24-h period
C Kaiser et al.
Journal of medicinal chemistry, 25(6), 697-703 (1982-06-01)
Resolution of the unique dopamine receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (1) was achieved by a stereospecific multistep conversion of the readily separated enantiomers of its O,O,N-trimethylated precursor 2. The absolute stereochemistry of the antipodes of 2-MeI was determined by single-crystal X-ray diffractometric
J L Katz et al.
Psychopharmacology, 107(2-3), 217-220 (1992-01-01)
The present study was designed to assess the behavioral similarity of the effects of prototype dopamine receptor-subtype selective agonists and cocaine. Squirrel monkeys (N = 4) were trained with food reinforcement to press one of two levers after administration of
E Ongini et al.
Life sciences, 37(24), 2327-2333 (1985-12-16)
The dopamine D-1 receptor agonist SKF 38393 dose-dependently (2.5-10 mg/kg) induced desynchronization of the electroencephalographic (EEG) activity and behavioral arousal in both rabbits and rats. Unlike apomorphine, SKF 38393 elicited no signs of stereotyped behavior in rabbits and minimal effects
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