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Merck

F0537

Sigma-Aldrich

壳梭孢菌素 来源于扁桃壳梭菌

≥85% (HPLC)

别名:

Fusicoccin A

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About This Item

经验公式(希尔记法):
C36H56O12
CAS号:
分子量:
680.82
MDL號碼:
分類程式碼代碼:
12352201
PubChem物質ID:
NACRES:
NA.25

生物源

plant (Fusicoccum amygdali)

品質等級

化驗

≥85% (HPLC)

形狀

solid

儲存溫度

−20°C

SMILES 字串

COCC1CCC2C(C)C(O)C(OC3OC(COC(C)(C)C=C)C(O)C(OC(C)=O)C3O)C4=C(CC(O)C4(C)C=C12)C(C)COC(C)=O

InChI

1S/C36H56O12/c1-10-35(6,7)45-17-26-30(41)33(46-21(5)38)31(42)34(47-26)48-32-28-24(18(2)15-44-20(4)37)13-27(39)36(28,8)14-25-22(16-43-9)11-12-23(25)19(3)29(32)40/h10,14,18-19,22-23,26-27,29-34,39-42H,1,11-13,15-17H2,2-9H3/b25-14-

InChI 密鑰

KXTYBXCEQOANSX-QFEZKATASA-N

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應用

壳梭孢菌素(壳梭孢菌素A)是一种二萜葡萄糖苷植物毒素,用于研究14-3-3-依赖性过程,例如植物和其他具有模式III结合基序的客户蛋白中H+-ATPase的激活。壳梭孢菌素是过氧化氢酶抑制剂的诱导剂,可导致植物氧化损伤。

其他說明

一种对植物具有多种生理效应的二萜糖苷。
为了全面了解我们针对客户研究提供的各种单糖产品,建议您访问我们的碳水化合物分类页面。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析证书(COA)

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Xiao-Ping She et al.
Physiologia plantarum, 140(3), 258-268 (2010-07-17)
Fusicoccin (FC) treatment prevents dark-induced stomatal closure, the mechanism of which is still obscure. By using pharmacological approaches and laser-scanning confocal microscopy, the relationship between FC inhibition of dark-induced stomatal closure and the hydrogen peroxide (H₂O₂) levels in guard cells
Christian Ottmann et al.
Molecular cell, 25(3), 427-440 (2007-02-10)
Regulatory 14-3-3 proteins activate the plant plasma membrane H(+)-ATPase by binding to its C-terminal autoinhibitory domain. This interaction requires phosphorylation of a C-terminal, mode III, recognition motif as well as an adjacent span of approximately 50 amino acids. Here we
Koshi Kawakami et al.
Anti-cancer agents in medicinal chemistry, 12(7), 791-800 (2012-01-24)
Malignant cells in solid tumors survive under prolonged hypoxia and can be a source of resistance to current cancer therapies. Tumor hypoxia is also associated with a more malignant phenotype and poor survival in cancer patients. Recent progress in our
Michiko Takahashi et al.
Angewandte Chemie (International ed. in English), 51(2), 509-512 (2011-11-23)
Fluorescent combination: Cell-penetrating probes derived from the diterpene fusicoccin can form ternary complexes with 14-3-3 proteins and phosphopeptide ligands, whereupon the probes site-specifically attach a fluorescent tag onto the surface of the 14-3-3 proteins.
Nicoletta Beffagna et al.
Physiologia plantarum, 142(2), 144-156 (2011-02-16)
The phytotoxin fusicoccin (FC) was found to induce an increase in apoplastic H₂O₂ content in Arabidopsis thaliana cells, apparently linked to the presence of an as yet unidentified catalase inhibitor detectable even in the external medium of FC-treated cells. This

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