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A8404

Sigma-Aldrich

盐酸阿米替林 盐酸盐

≥98% (TLC), powder

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About This Item

经验公式（希尔记法）:
C20H23N · HCl
CAS号:
549-18-8
分子量:
313.86
EC號碼:
208-964-6
MDL號碼:
MFCD00012537
分類程式碼代碼:
12352200
PubChem物質ID:
24278073
NACRES:
NA.77

化驗

≥98% (TLC)

形狀

powder

顏色

white to off-white

溶解度

H2O: soluble
ethanol: soluble

起源

Bristol-Myers Squibb

儲存溫度

2-8°C

SMILES 字串

Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

InChI 密鑰

KFYRPLNVJVHZGT-UHFFFAOYSA-N

基因資訊

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , SLC6A2(6530) , SLC6A4(6532)

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應用

盐酸阿密曲替林已用于：
  • 研究其作为抗抑郁药对酸性鞘磷脂酶转基因(t-ASM)小鼠社会行为和记忆的影响
  • 分析其作为三环类抗抑郁药物对人全血中糖皮质受体功能的影响
  • 研究其作为抗抑郁药对氯喹诱导小鼠搔抓和运动行为的影响

生化／生理作用

三环类抗抑郁药；抑制去甲肾上腺素和5-羟色胺转运蛋白，Kis分别为100 nM和14.7 nM；对α1-肾上腺素能受体，5-羟色胺和毒蕈碱乙酰胆碱受体具有高体外亲和力。
盐酸阿密曲替林(Amitriptyline)可用于治疗焦虑、躁郁和更年期抑郁症。它具有抗组胺、抗胆碱和抗血清素特性。盐酸阿密曲替林是两亲性药物，具有神经抑制活性。

特點和優勢

粉末的保质期至少为三年。

相關產品

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说明
价格

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Neha Maurya et al.
Journal of biomolecular structure & dynamics, 35(6), 1367-1380 (2016-05-05)
Herein, we have explored the interaction between amitriptyline hydrochloride (AMT) and hemoglobin (Hb), using steady-state and time-resolved fluorescence spectroscopy, UV-visible spectroscopy, and circular dichroism spectroscopy, in combination with molecular docking and molecular dynamic (MD) simulation methods. The steady-state fluorescence reveals
Nadine Beckmann et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(4), 1460-1471 (2017-10-17)
Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial joints. Treatment is hampered by the lack of a cure and current disease-modifying drugs are associated with potentially severe toxicities. We investigated arthritis severity by measuring joint swelling
Iulia Zoicas et al.
PloS one, 11(9), e0162498-e0162498 (2016-09-07)
Major depressive disorder is often associated with deficits in social and cognitive functioning. Mice transgenic for acid sphingomyelinase (t-ASM) were previously shown to have a depressive-like phenotype, which could be normalized by antidepressant treatment. Here, we investigated whether t-ASM mice
L A Carvalho et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 20(6), 379-387 (2010-03-17)
Clinical studies have demonstrated an impairment of glucocorticoid receptor (GR)-mediated negative feedback on the hypothalamic-pituitary-adrenal (HPA) axis in patients with major depression (GR resistance), and its resolution by antidepressant treatment. Recently, we showed that this impairment is indeed due to
Olga Ilnytska et al.
The Journal of biological chemistry, 297(1), 100813-100813 (2021-05-24)
Niemann-Pick C (NPC) is an autosomal recessive disorder characterized by mutations in the NPC1 or NPC2 genes encoding endolysosomal lipid transport proteins, leading to cholesterol accumulation and autophagy dysfunction. We have previously shown that enrichment of NPC1-deficient cells with the
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