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E6657

Sigma-Aldrich

Eplerenone

≥98% (HPLC)

别名:

9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester, Cgp 30083, Eplerenone [USAN], Epoxymexrenone, HSDB 7522, Inspra, Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-, SC-66110

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About This Item

经验公式（希尔记法）:
C24H30O6
CAS号:
107724-20-9
分子量:
414.49
MDL號碼:
MFCD05662207
分類程式碼代碼:
51111800
PubChem物質ID:
329798999
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear (warmed)
H2O: insoluble

儲存溫度

2-8°C

SMILES 字串

O1[C@]32[C@H]1C[C@@]4([C@@]6(OC(=O)CC6)CC[C@H]4[C@@H]3[C@@H](CC5=CC(=O)CC[C@@]52C)C(=O)OC)C

InChI

1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

InChI 密鑰

JUKPWJGBANNWMW-VWBFHTRKSA-N

基因資訊

human ... NR3C2(4306)

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一般說明

Eplerenone is an aldosterone blocker, which particularly blocks mineralocorticoid receptor. It reduces cardiovascular risk in patients following acute myocardial infarction. Eplerenone is used for treating hypertension and central serous retinopathy. It exhibits potassium sparing diuretic effect.

應用

Eplerenone has been used in quantitative real time (RT-qPCR) or western blotting assays.

生化／生理作用

Eplerenone is an aldosterone antagonist more specific for the mineralocorticoid receptor than spironolactone (S3378), having lower affinity for progesterone, androgen, and glucocorticoid receptors.
Eplerenone is an aldosterone antagonist.

特點和優勢

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
114M4742V
122M4725V
109K47222V
031M4731V
031M4713V

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Tracy Ann Williams et al.
The Journal of clinical endocrinology and metabolism, 100(9), E1262-E1269 (2015-07-16)
Coexisting prolactinoma-primary aldosteronism (PA) is infrequently reported. The objective of the study was to identify patients with prolactinoma-PA and test the hypothesis that elevated prolactin (PRL) concentrations play a role in PA pathogenesis. Hyperprolactinemia/prolactinoma was diagnosed in PA patients from
C Mondadori et al.
Psychopharmacology, 124(4), 380-383 (1996-04-01)
The retention performance of mice in a passive-avoidance task was facilitated by low doses (0.3 mg/kg) of the competitive NMDA-receptor blocker CGP 37849, but impaired by high doses (30 mg/kg). The facilitatory effect was selectively suppressed by elevation of the
Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
Pitt B, et al.
The New England Journal of Medicine, 348(14), 1309-1321 (2003)
Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension
Weinberger MH, et al.
American Journal of Hypertension, 15(8), 709-716 (2002)
M de Gasparo et al.
Journal of steroid biochemistry, 32(1B), 223-227 (1989-01-01)
The use of spironolactone in the treatment of hypertension has been limited by the occurrence of sexual side effects, mainly menstrual disturbances in women and gynaecomastia in men. In order to minimize this limitation on the use of an effective
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