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D6140

Sigma-Aldrich

地美环素 盐酸盐

powder or crystals, suitable for cell culture

别名:

7-Chloro-6-demethyltetracycline hydrochloride, Demethylchlorotetracycline hydrochloride

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About This Item

经验公式（希尔记法）:
C21H21ClN2O8 · HCl
CAS号:
64-73-3
分子量:
501.31
Beilstein:
3849198
EC號碼:
200-592-2
MDL號碼:
MFCD00082371
分類程式碼代碼:
12352207
PubChem物質ID:
24278380
NACRES:
NA.75

product name

地美环素 盐酸盐, powder or crystals

化驗

89.5-102.0% anhydrous basis

品質等級

200

形狀

powder or crystals

技術

cell culture | mammalian: suitable

溶解度

soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

protein synthesis | interferes

儲存溫度

−20°C

SMILES 字串

Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O

InChI

1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1

InChI 密鑰

GVSJQNRGSCOSNJ-KBHRXELFSA-N

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相关类别

一般說明

Chemical structure: tetracycline

生化／生理作用

Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.
Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Warning

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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P Lenherr et al.
International endodontic journal, 45(10), 942-949 (2012-04-18)
To investigate the discoloration potential of endodontic materials using a bovine tooth model. Two hundred and 10 dentine-enamel cuboid blocks (10 × 10 × 3.5 mm) were prepared out of the middle thirds of bovine tooth crowns. Standardized cavities were
Quan V Ho et al.
Journal of endodontics, 36(1), 119-122 (2009-12-17)
Traditional culture-based techniques for assessing infection of the root canal system are difficult to use and prone to error. Real-time assessment of the microbial status of the root canal system using laser fluorescence would help address these limitations. This study
M Athanassiadis et al.
International endodontic journal, 44(12), 1162-1169 (2011-09-10)
To investigate the chemical interaction of calcium hydroxide with the corticosteroid triamcinolone acetonide in Ledermix Paste and in Odontopaste, a new steroid/antibiotic paste. Validated methods were developed to analyse the interaction of calcium hydroxide in two forms, Pulpdent Paste and
B Athanassiadis et al.
Australian dental journal, 55(3), 298-305 (2010-10-05)
The aim of this study was to investigate the antimicrobial effect of endodontic medicaments and their bases in the presence of dentine powder. The medicaments tested were Ledermix paste, Pulpdent paste, a 50:50 combination of the Pulpdent:Ledermix and their bases.
Peter F Day et al.
Journal of endodontics, 37(8), 1052-1057 (2011-07-19)
There is evidence to suggest that Ledermix, placed as an intervisit root canal dressing, might improve periodontal healing after replantation of avulsed teeth. As a part of a multicenter randomized controlled trial, we aimed to compare the effect of 2
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