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26430

Sigma-Aldrich

金霉素盐酸盐 盐酸盐

suitable for fluorescence, BioReagent, from Streptomyces aureofaciens, ≥85.0% (HPLC)

别名:

金霉素 盐酸盐

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About This Item

经验公式（希尔记法）:
C22H23ClN2O8 · HCl
CAS号:
64-72-2
分子量:
515.34
Beilstein:
3858364
EC號碼:
200-591-7
MDL號碼:
MFCD00082440
分類程式碼代碼:
51102829
PubChem物質ID:
57648175
NACRES:
NA.85

生物源

Streptomyces aureofaciens

產品線

BioReagent

化驗

≥85.0% (HPLC)

形狀

powder or crystals

顏色

faintly yellow to yellow

mp

210-215 °C (dec.) (lit.)

溶解度

H2O: 50 mg/mL

適合性

suitable for fluorescence

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

protein synthesis | interferes

儲存溫度

−20°C

SMILES 字串

Cl.CN(C)[C@H]1[C@@H]2CC3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O

InChI

1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7?,8-,15-,21-,22-;/m0./s1

InChI 密鑰

CBHYYLPALVVVEY-LYNLVHCPSA-N

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相关类别

一般說明

Chemical structure: tetracycline

應用

Cell-permeable fluorescent probe for Ca2+ for measuring calcium flux in endoplasmic reticulum and other intracellular stores in situ.

生化／生理作用

Chlortetracycline is an antibiotic produced by some strains of Streptomyces aureofaciens.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-positive. Less active against Gram-negative bacteria than tetracycline.
Mode of Resistance: Loss of cell wall permeability.

包裝

5 g, 25 g, 100g

品質

Recommended for fluorescent studies of calcium signaling in cells or tissues.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Warning

危險分類

Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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Changlong Gou et al.
Bioresource technology, 323, 124517-124517 (2020-12-29)
Chlorotetracycline (CTC) is one of the most antibiotics present in cattle manure. In present study, three levels of CTC (0, 20 and 40 mg kg-1) were added to cattle manure composting systems to investigate its effects on the distribution of antibiotic-resistant genes
Kenneth N Agwuh et al.
The Journal of antimicrobial chemotherapy, 58(2), 256-265 (2006-07-04)
The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups. Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, demeclocycline, lymecycline, methacycline and rolitetracycline is characterized by poor absorption after food. Group 2, represented by doxycycline and minocycline
Claudia Cerella et al.
Annals of the New York Academy of Sciences, 1099, 490-493 (2007-04-21)
Many studies suggest that endoplasmic reticulum (ER) Ca2+ pool rather than cytosolic Ca2+ may play a crucial role in triggering apoptosis. In this study, we performed an image analysis of cells loaded with the fluorescent dye chlortetracycline (CTC) to in
A E Oliver et al.
Biophysical journal, 78(4), 2116-2126 (2000-03-29)
The effect of temperature on the binding equilibria of calcium-sensing dyes has been extensively studied, but there are also important temperature-related changes in the photophysics of the dyes that have been largely ignored. We conducted a systematic study of thermal
Lindsay Gillan et al.
Theriogenology, 63(2), 445-457 (2005-01-01)
Most laboratory methods used to evaluate semen quality have not correlated highly with fertilizing capacity. The discovery of a variety of fluorochromes and compounds conjugated to fluorescent probes has enabled a more widespread analysis of sperm attributes, and in conjunction
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