T4062

四环素 盐酸盐

meets USP testing specifications

• 别名: Tetracycline HCL
• 经验公式（希尔记法）: C₂₂H₂₄N₂O₈ · HCl
• CAS号: 64-75-5
• 分子量: 480.90
• Beilstein: 3844873
• EC號碼: 200-593-8
• MDL號碼: MFCD00078142
• 分類程式碼代碼: 51284043
• PubChem物質ID: 24900192
• NACRES: NA.76

属性

• agency: USP/NF; meets USP testing specifications
• 品質等級: 200
• 化驗: ≥900 (Units in µg/mg)
• 形狀: crystalline powder
• 光學活性: [α]/D -255 to 240° (Specific rotation )
• 儲存條件: (Keep container tightly closed in a dry and well-ventilated place. Light sensitive.)
• 雜質: ≤4.0%
• 顏色: yellow
• mp: 220-223 °C (lit.)
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria
• 應用: pharmaceutical (small molecule)
• 作用方式: protein synthesis | interferes
• 儲存溫度: −20°C
• SMILES 字串: Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
• InChI 密鑰: XMEVHPAGJVLHIG-FMZCEJRJSA-N

说明

一般說明

Chemical structure: tetracycline

應用

Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis. It is recommended for use in cell culture applications at 10 mg/L.

生化／生理作用

作用机制：四环素通过细胞膜中的 proin 通道被动扩散，与 30S 核糖体结合，并通过阻止氨酰基 tRNA 进入 mRNA-核糖体复合物上的受体位点来抑制蛋白质合成。它也与细菌的 50S 核糖体亚基结合，改变膜并导致细胞内成分从细菌细胞中泄漏。通过洗涤可以逆转抑制作用，这表明起到抗菌作用的是可逆结合的抗生素，而不是不可逆结合的药物。

耐药性机制：这种作用通过细胞壁通透性的丧失而失活。

抗菌谱：包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。

注意

This product should be frozen below 0°C and protected from light and moisture. In these conditions, the product has been shown to retain activity for 4 years. Stock solutions should be stored at -20°C and are stable at 37°C for 4 days.

準備報告

The product is freely soluble in water, soluble in methanol and ethanol but is insoluble in ether and hydrocarbons. In water, the product yields a clear, yellow-orange solution with heating and in 95% ethanol, 50 mg dissolved in 4 mL with heating yields a clear, yellow-green solution. Tetracycline is rapidly destroyed by alkali hydroxide solutions and standing water solutions become turbid due to hydrolysis and precipitation. The potency of tetracycline is reduced in solutions with pH below 2.

其他說明

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.

安全信息

• 象形圖: GHS08,GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H315,H319,H335,H361fd,H410
• 防範說明: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• 危險分類: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves