推荐产品
生物源
synthetic (organic)
品質等級
化驗
≥98% (HPLC)
形狀
solid
mp
107-109 °C
溶解度
DMSO: 1 mg/mL, clear, colorless to faintly yellow
儲存溫度
2-8°C
InChI
1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
InChI 密鑰
RVOUDNBEIXGHJY-UHFFFAOYSA-N
應用
在体内研究中，DPQ已被用作一种PARP 1（聚(ADP-核糖)聚合酶1）抑制剂，用于确定辐照后γ-H2AX（H2A组蛋白家族成员X）的损失。
生化／生理作用
在局部缺血的影响下，已知3,4-二氢-5-[4-(1-哌啶基)丁氧基]-1(2H)-异喹啉酮（DPQ）可降低PARP 1（聚(ADP-核糖)聚合酶1）介导的细胞凋亡。它被认为是比传统使用的PARP1抑制剂3-氨基苯甲酰胺更有效的抑制剂。
DPQ是一种非常有效的聚(ADP-核糖)聚合酶（PARP）抑制剂。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Parp1-XRCC1 and the repair of DNA double strand breaks in mouse round spermatids
Ahmed EA, et al.
Mutation Research, 683(1), 84-90 (2010)
Ujval Anilkumar et al.
PloS one, 12(11), e0188343-e0188343 (2017-11-18)
Cell death induced by excessive glutamate receptor overactivation, excitotoxicity, has been implicated in several acute and chronic neurological disorders. While numerous studies have demonstrated the contribution of biochemically and genetically activated cell death pathways in excitotoxic injury, the factors mediating
M J Suto et al.
Anti-cancer drug design, 6(2), 107-117 (1991-05-01)
A series of dihydroisoquinolinones, formally rigid analogs of 3-substituted benzamides, and a series of 2,3-disubstituted benzamides were synthesized and evaluated as inhibitors of poly(ADP-ribose) polymerase. The results indicated that the orientation of the amide with respect to the substituent on
Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses, 29-29 (2012)
M J Eliasson et al.
Nature medicine, 3(10), 1089-1095 (1997-10-23)
Nitric oxide (NO) and peroxynitrite, formed from NO and superoxide anion, have been implicated as mediators of neuronal damage following focal ischemia, but their molecular targets have not been defined. One candidate pathway is DNA damage leading to activation of
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门