D4321

Dihydroeponemycin

≥98% (HPLC)

• 经验公式（希尔记法）: C₂₀H₃₆N₂O₆
• CAS号: 126463-64-7
• 分子量: 400.51
• MDL號碼: MFCD17215971
• 分類程式碼代碼: 12352202
• PubChem物質ID: 329798798
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 光學活性: [α]/D ±35.7°
• 顏色: off-white to light tan
• 溶解度: DMSO: ≥1 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: CC(C)CCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(CO)CO1
• InChI: 1S/C20H36N2O6/c1-13(2)7-5-6-8-17(25)21-16(10-23)19(27)22-15(9-14(3)4)18(26)20(11-24)12-28-20/h13-16,23-24H,5-12H2,1-4H3,(H,21,25)(H,22,27)/t15-,16-,20+/m0/s1
• InChI 密鑰: IUDBVFIQSSOIDB-TWOQFEAHSA-N

说明

生化／生理作用

Dihydroeponemycin is an active derivative of eponemycin an antitumor antibiotic isolated from Streptomyces hygroscopicus. Dihydroeponemycin labels the catalytic threonine residues of the immunoproteasome subunits LMP2 and LMP7 and the constitutive proteasome subunit X, while epoxomicin covalently modifies the N-terminal catalytic threonine residues of the constitutive proteasome (X and Z) and immunoproteasome (LMP7 and MECL1) subunits.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable