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生物源
plant (Silybum marianum)
品質等級
形狀
powder
技術
toxicology assay: suitable
應用
microbiology
儲存溫度
−20°C
InChI
1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3
InChI 密鑰
SEBFKMXJBCUCAI-UHFFFAOYSA-N
一般說明
水飞蓟素是一种黄酮木脂素，来自奶蓟（水飞蓟）植物。
應用
水飞蓟素已用于研究：
- 其体外抗病毒、抗菌、抗真菌活性及细胞毒性
- 水飞蓟素对环磷酰胺 (CYP) 诱导的膀胱炎大鼠模型膀胱收缩的影响
- 其对伏马菌素 B1 诱导的小鼠肝脏中毒的影响
生化／生理作用
水飞蓟素对大鼠缺血再灌注诱导的心肌梗死具有心脏保护活性。
水飞蓟素最初是众所周知的保护肝脏免受各种有毒物质侵害的药物，并用于治疗肝炎和肝硬化。水飞蓟素具有抗纤维化、抗脂质过氧化、抗炎、免疫调节和膜稳定等多种生物学作用。水飞蓟素还有助于肝再生。
水飞蓟素通过降低血清丙氨酸氨基转移酶 (ALT)、天门冬氨酸氨基转移酶 (AST) 和碱性磷酸酶 (ALP) 水平来保护肝脏免受抗结核药物的细胞毒作用。这种作用与水飞蓟素的抗氧化作用有关。
其他說明
水飞蓟 果实中抗肝毒性黄酮醇木脂素的混合物。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Chun-Ping Lu et al.
Chemico-biological interactions, 290, 12-18 (2018-05-14)
Macrophages and inflammasome pathway are involved in high-glucose toxicity and development of insulin resistance. Silymarin (SMR) was known to modulate glucose homeostasis and reduce inflammation. However, it is still unknown whether SMR possess anti-hyperglycemic effects in diabetic-like knockout mice (Hnf-1αkin/-/Ins.cre
Silymarin Restores Regulatory T Cells (Tregs) Function in Multiple Sclerosis (MS) Patients In Vitro.
Maryam Shariati et al.
Inflammation, 42(4), 1203-1214 (2019-02-27)
Dysregulation of the immune system and impairment in the function and number of patient-derived regulatory T cells (Treg) have an important role in multiple sclerosis (MS) pathogenesis. MS patients still receive different medications to overcome the relapses and to slow
Verônica de Souza Santos et al.
Life sciences, 228, 305-315 (2019-05-03)
Silymarin, an extract from Silybum marianum (milk thistle) containing a standardized mixture of flavonolignans that ameliorates some types of liver disease and, more recently, kidney damage, could be used for the ROS-scavenging effect of these antioxidants. Furthermore, contrast-induced nephropathy (CIN)
Vieri Piazzini et al.
Molecules (Basel, Switzerland), 24(9) (2019-05-06)
Two novel nanomicellar formulations were developed to improve the poor aqueous solubility and the oral absorption of silymarin. Polymeric nanomicelles made of Soluplus and mixed nanomicelles combining Soluplus with d-α-tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS) were prepared using
Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals.
Eminzade, S.
Nutrition & Metabolism, 5, 18-18 (2008)
商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
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