PHR1700

利巴韦林

Pharmaceutical Secondary Standard; Certified Reference Material

• 别名: 利巴韦林, 1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺
• 经验公式（希尔记法）: C₈H₁₂N₄O₅
• CAS号: 36791-04-5
• 分子量: 244.20
• MDL號碼: MFCD00058564
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329823563
• NACRES: NA.24

属性

• 等級: certified reference material; pharmaceutical secondary standard
• 品質等級: 300
• agency: traceable to BP 593; traceable to Ph. Eur.; traceable to USP 1602706
• API 家族: ribavirin
• CofA: current certificate can be downloaded
• 包裝: pkg of 1 g
• 技術: HPLC: suitable; gas chromatography (GC): suitable
• 應用: pharmaceutical (small molecule)
• 形式: neat
• 儲存溫度: 2-8°C
• SMILES 字串: NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
• InChI: 1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
• InChI 密鑰: IWUCXVSUMQZMFG-AFCXAGJDSA-N
• 基因資訊: human ... IMPDH1(3614)

说明

一般說明

嘌呤核苷酸生物合成中咪唑核苷酸中间体的类似物。

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards

Ribavirin is a synthetic guanosine analog, effective against respiratory syncytial virus, several hemorrhagic fever viruses and human immuno deficiency virus.Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

應用

Ribavirin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high-pressure liquid chromatographic method.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化／生理作用

用于抵御多种人类病毒感染的抗病毒剂，特别是慢性肝炎C、HIV 和腺病毒。其代谢产物利巴韦林 5′-磷酸，是肌苷一磷酸 (IMP) 脱氢酶的抑制剂，但也有实验证据支持许多其他作用机制。

分析報告

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAA6966 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H341,H360FD
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Muta. 2 - Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable