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Merck

D1415

Sigma-Aldrich

4,6-二氧庚酸

powder

别名:

琥珀酰丙酮

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About This Item

线性分子式:
CH3COCH2COCH2CH2CO2H
CAS号:
分子量:
158.15
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.25

形狀

powder

品質等級

mp

66-67 °C (lit.)

脂質類型

saturated FAs

儲存溫度

2-8°C

SMILES 字串

CC(=O)CC(=O)CCC(O)=O

InChI

1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11)

InChI 密鑰

WYEPBHZLDUPIOD-UHFFFAOYSA-N

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應用

4,6-二氧庚酸已用于:
  • 作为树突状细胞条件培养基组分并抑制树突状细胞中的ALA脱水酶(ALAD)(50)
  • 作为人单个核细胞(51)和HeLa细胞(52)中的血红素的生物合成抑制剂
  • 作为恶性疟原虫培养物中的琥珀酰丙酮的定量标准品(53)

生化/生理作用

4,6-二氧庚酸是一种血红素生物合成抑制剂。它是酪氨酸分解的代谢副产物,可抑制δ氨基酮戊酸(ALA)脱水酶。它是检测酪氨酸血症Ⅰ型的潜在标志物,是新生儿干血斑分析的检测目标。
血红素生物合成抑制剂

相關產品

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Succinylacetone as primary marker to detect tyrosinemia type I in newborns and its measurement by newborn screening programs
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The effects of levulinic acid and 4, 6-dioxoheptanoic acid on the metabolism of etiolated and greening barley leaves
Meller E and Gassman ML
Plant Physiology, 67(4), 728-732 (1981)

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