NCI-H322 Cell Line human
NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA, 95111734, human lung (cervical node metastasis), Not specified
别名:
H322 Cells, NCI-322 Cells, NCI-H322T Cells
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About This Item
分類程式碼代碼:
41106514
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生物源
human lung (cervical node metastasis)
描述
Human Caucasian bronchioalveolar carcinoma
包裝
tube of 5 μg 95111734-DNA-5UG
pkg of vial of cells 95111734-1VL
增長模式
Adherent
染色體組型
Not specified
形態學
Not specified
產品
Not specified
受體
Not specified
技術
cell culture | mammalian: suitable
相關疾病
metastasis
運輸包裝
dry ice
儲存溫度
−196°C
細胞系來源
Human Caucasian bronchioalveolar carcinoma
細胞系描述
NCI-H322 was derived in 1981 from a primary bronchioalveolar carcinoma of the lung from a 52 year old male taken prior to treatment. Ultrastructural studies of this non-small cell carcinoma cell line demonstrated the presence of cytoplasmic structures characteristic of Clara cells. NCI-H322 do not express UDP-glucuronosyltransferase, but are reported to express glutathione-S-transferase and phenol sulfotransferase. Expression of protein and RNA of SP-A, the major surfactant-associated protein was detected. The cells produce tumours in athymic mice.
應用
NCI-H322 has been used to study the preclinical antitumor efficacy of BAY 1129980, which is an anti-C4.4A (Ly6/PLAUR domain-containing protein 3 precursor-LYPD3) antibody–drug conjugate for the treatment of non–small cell lung cancer.
Test system for evaluating cytotoxicity and genotoxicity of chemicals to human lung
培養基
RPMI 1640 + 2mM Glutamine + 5-10% Foetal Bovine Serum (FBS).
例行更新培養
Split sub-confluent cultures (70-80%) 1:3 to 1:6 i.e. seeding at 1-3x10,000 cells/cm2 using 0.25% trypsin or trypsin/EDTA; 5% CO2; 37°C.
其他說明
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