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Merck

C7736

Sigma-Aldrich

Anti-Centrin antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-CEN1, Anti-CETN

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 21 kDa

物種活性

human

技術

microarray: suitable
western blot: 1:2,000 using 293-T exp.Hu.Centrin-1LY117608 or 293-T exp.Hu.Centrin1-FLAG LY401316

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... CETN1(1068)

一般說明

Centrins are acidic proteins, that are usually found in all eukaryotes. Centrin 1 (CETN1), an intron-less gene is mapped on human chromosome 18p11. It possesses certain features of an expressed retroposon.
The centrosome, the major microtubule-organizing center (MTOC) in the animal cell, is a key determinant in the organization of the cytoplasm, in the determination of cell polarity, and in the establishment of mitotic spindle poles during the cell cycle. Centrin is a member of the calcium binding E-F hand protein superfamily present in the centrosome pericentriolar matrix.
Three separate centrin genes have been identified in human cells: centrin 1, 2, and 3. Centrin 1 shows strong amino acid homology to centrin 2 (85%), but lower homology to centrin 3 (54%) and CDC31 (50%) from the yeast S. cerevisiae. Centrin has a fundamental role in the MTOC structure and function. Phenotypic analysis of mutants in Chlamydomonas caltractin and the yeast CDC31 genes have indicated that the protein is required for proper duplication and segregation of the MTOC in the respective cells.

免疫原

synthetic peptide corresponding to the C-terminus of human centrin 1 (amino acids 157-172). The sequence is highly conserved in centrin 1 of many species, e.g. mouse, Drosophila, and Xenopus. It is also found in human and mouse centrin 2, but is not found in centrin 3.

應用

Anti-Centrin antibody produced in rabbit has been used in:
  • immunofluorescence
  • immunoblotting
  • immunofluorescence microscopy

生化/生理作用

Centrin has a fundamental role in the microtubule-organizing center (MTOC) structure and function. These proteins has imperative roles in centrosome positioning and segregation. Centrin also participates in cytokinesis and cell cycle progression.

外觀

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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访问文档库

Asterless is a scaffold for the onset of centriole assembly
Dzhindzhev NS, et al.
Nature, 467(7316), 714-718 (2010)
DNA Damage-Induced Accumulation of Centrosomal Chk1 Contributes to its Checkpoint Function
Looffler H, et al.
Cell Cycle, 6(20), 2541-2548 (2007)
CETN1 is a cancer testis antigen with expression in prostate and pancreatic cancers
Kim JJ, et al.
Biomarker research, 1, 22-22 (2013)
M E Lachowicz-Scroggins et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 47(12), 1534-1545 (2017-08-24)
Bronchial epithelial goblet cell metaplasia (GCM) with hyperplasia is a prominent feature of asthma, but the effects of treatment with corticosteroids alone or in combination with a long-acting β To determine whether corticosteroid alone or in combination with a LABA
Optimization of purification method and characterization of recombinant human Centrin-1
Phanindranath R, et al.
Protein Expression and Purification, 124, 48-54 (2016)

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