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生物源
bovine spleen
品質等級
形狀
lyophilized powder
比活性
≥10 units/mg protein
成份
Protein, ≥30% biuret
UniProt登錄號
儲存溫度
−20°C
基因資訊
cow ... CTSB(281105)
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一般說明
组织蛋白酶B是一种溶酶体酶，由一条轻链(Lys1–Arg49)和一条重链(Val50–Thr253)组成。属于半胱氨酸蛋白酶C1家族成员。
應用
牛脾组织蛋白酶B已用于组织蛋白酶B的酶切实验，产物进行高效液相色谱-质谱(HPLC-MS)分析。它也与蛋白酶抑制剂RfIP1和钌金属脂芳烃(ruthenium metalloarene)共同用于酶抑制分析。
生化／生理作用
组织蛋白酶B具有肽链内切酶和肽基二肽酶活性。它可能与肿瘤的病理生理状况有关。组织蛋白酶B也是利什曼病的标志蛋白酶。它在肌肉营养不良、肺气肿和骨吸收中过度激活。
组织蛋白酶B已被发现可切割胱天蛋白酶原1和胱天蛋白酶原11，并在洋地黄皂苷透化细胞中诱导细胞凋亡。组织蛋白酶B从细胞质向细胞核的转移促进了胆盐诱导的大鼠肝细胞凋亡。在诱导细胞凋亡后12至24小时，PC12细胞中组织蛋白酶B的水平显著降低。
單位定義
在pH 5.0 25 °C条件下，一个单位可在每分钟水解1 μmole Z-赖氨酸对硝基苯酯。
外觀
含有磷酸钠、氯化钠和~6％ EDTA作为稳定剂的冻干粉。
基底
抑制劑
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Angela Casini et al.
Journal of medicinal chemistry, 51(21), 6773-6781 (2008-10-07)
A series of ruthenium(II)-arene (RAPTA) compounds were evaluated for their ability to inhibit thioredoxin reductase (either cytosolic or mitochondrial) and cathepsin B, two possible targets for anticancer metallodrugs. In general, inhibition of the thioredoxin reductases was lower than that of
Angela Casini et al.
Dalton transactions (Cambridge, England : 2003), 39(23), 5556-5563 (2010-05-15)
A series of organometallic compounds of general formula [(arene)M(PTA)(n)X(m)]Y (arene = eta(6)-C(10)H(14), eta-C(5)Me(5)); M = Ru(ii), Os(ii), Rh(iii) and Ir(iii); X = Cl, mPTA; Y = OTf, PF(6)) have been screened for their cytotoxicity and ability to inhibit cathepsin B
Abir Ben Bacha et al.
3 Biotech, 7(2), 148-148 (2017-06-10)
Protease inhibitors from plants are well known to be potent inhibitors of the growth of bacteria, fungi, and even certain viruses which make them excellent candidates for use as the lead compounds for the development of novel antimicrobial agents for
Pasquale Mura et al.
Journal of inorganic biochemistry, 104(2), 111-117 (2009-11-27)
A novel ruthenium(II) compound, trans-cis-cis-[Ru(II)Cl(2)(DMSO)(2)(2-amino-5-methyl-thiazole)(2)], (I), PMRu52 hereafter, that may be obtained from the previously described (cis and trans)-[Ru(II)Cl(2)(DMSO)(4)] complexes, was designed, synthesized and characterised. The single crystal X-ray structure shows a roughly regular octahedral environment for the ruthenium(II) center
M A Sentandreu et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 81(4), 317-326 (2003-10-22)
Cathepsin B (EC 3.4.22.1) has been highly purified (14,225 fold) from bovine kidney by a rapid procedure that included the preparation of an enriched lysosomal extract, a selective fractionation with ammonium sulphate, size-exclusion chromatography, two cation-exchange chromatographies, and anion-exchange chromatography
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