推荐产品
生物源
human leucocytes
品質等級
形狀
lyophilized powder
比活性
≥60 units/mg protein (Bradford)
分子量
23-30 kDa
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... CTSG(1511)
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一般說明
Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.
應用
Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.
生化／生理作用
Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.
Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.
單位定義
One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.
外觀
Lyophilized from 0.5 M pyridinium acetate, pH 5.3.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Immunology Letters, 179, 80-84 (2016)
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