推荐产品
應用
经 PEG-过氧化氢酶处理的肺动脉内皮细胞可有效抑制 20-HETE(羟基二十碳四烯酸)诱导的荧光增强。但实验排除了 DCF(二氯荧光素)潜在的非特异性荧光。本实验研究了 20-HETE 对超氧化物产生和 NADPH 氧化酶活化的影响。
生化/生理作用
来自牛肝的过氧化氢酶催化 H 2 O 2 分解为水和氧。是一种四聚体,由分子量为 60 kDa 的四个相等的亚单位组成。每个亚基均含有与血红素 IX 基团结合的铁。该酶还能与靠近血红素基团的 NADP 强烈结合。过氧化氢酶活性在 pH 4.0-8.5 范围内恒定。pI 为 5.4。3-氨基-1-H-1,2,4 三唑、氰化物、叠氮化物、羟胺、溴化氰、2-巯基乙醇、二硫苏糖醇、联茴香胺和硝酸盐可抑制酶活性。用抗坏血酸或抗坏血酸/Cu 2 + 孵育过氧化氢酶会导致过氧化氢酶分子的降解。它不需要任何激活剂。
包裝
基于蛋白质含量的包装规格
其他說明
来自牛肝脏的过氧化氢酶偶联甲氧基-聚乙二醇。
外觀
含 PEG 加 5% 柠檬酸盐缓冲盐
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Nature communications, 7, 10399-10399 (2016-01-30)
The main characteristic of senescence is its stability which relies on the persistence of DNA damage. We show that unlike fibroblasts, senescent epithelial cells do not activate an ATM-or ATR-dependent DNA damage response (DDR), but accumulate oxidative-stress-induced DNA single-strand breaks
Free radical biology & medicine, 112, 534-543 (2017-08-28)
ERK-dependent signaling is key to many pathways through which extracellular signals are transduced into cell-fate decisions. One conundrum is the way in which disparate signals induce specific responses through a common, ERK-dependent kinase cascade. While studies have revealed intricate ways
PloS one, 5(9), e12712-e12712 (2010-09-22)
Senescence is a state of growth arrest resulting mainly from telomere attrition and oxidative stress. It ultimately leads to cell death. We have previously shown that, in keratinocytes, senescence is induced by NF-kappaB activation, MnSOD upregulation and H(2)O(2) overproduction. We
Cell reports, 8(3), 883-896 (2014-07-30)
Neutrophils contain granules loaded with antimicrobial proteins and are regarded as impermeable organelles that deliver cargo via membrane fusion. However, during the formation of neutrophil extracellular traps (NETs), neutrophil elastase (NE) translocates from the granules to the nucleus via an
Circulation research, 91(5), 406-413 (2002-09-07)
Angiotensin II (Ang II)-stimulated hypertrophy of vascular smooth muscle cells is mediated by reactive oxygen species (ROS) derived from NAD(P)H oxidases. The upstream signaling mechanisms by which Ang II activates these oxidases are unclear but may include protein kinase C
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门