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Merck

C4905

Sigma-Aldrich

Galactocerebrosides from bovine brain

≥97% (TLC)

别名:

Ceramide β-D-galactoside

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About This Item

CAS号:
MDL號碼:
分類程式碼代碼:
12352211
NACRES:
NA.77

品質等級

化驗

≥97% (TLC)

形狀

powder

儲存溫度

−20°C

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一般說明

A mixture of type I (containing α-hydroxy fatty acid) and type II (containing non-hydroxy fatty acid) cerebrosides. Galactocerebroside (GalCer) is a glycosphingolipid, that consists of a single galactose residue, connected to ceramide . GalCer is present within the exofacial leaflet of the lipid bilayer.

應用

Galactocerebrosides from bovine brain has been used to find the receptor activity of surface-immobilized galactosylceramide. It has also been used in sulfatide binding assay.

生化/生理作用

Galactocerebroside (GalCer) participates in the progression and maintenance of myelin. This oligodendroglial lipid is used as an immunohistochemical tool for studying oligodendrocytes.
Galactose linked to ceramide by a β-glycosidic linkage; the major lipid in adult brain, representing approximately 16% of total lipid; they are mainly localized to myelin and are markedly reduced in demyelinating diseases.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析证书(COA)

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Piglet ileal mucus contains protein and glycolipid (galactosylceramide) receptors specific for Escherichia coli K88 fimbriae.
Blomberg L, et al.
Infection and Immunity, 61(6), 2526-2531 (1993)
Gangliosides and Autoimmune Peripheral Nerve Diseases
Progress in Molecular Biology and Translational Science, 156, 355-382 (2018)
Oligodendrocyte morphology
Encyclopedia of Neuroscience (2009)
Scaffold-forming and adhesive contributions of synthetic laminin-binding proteins to basement membrane assembly
McKee K K, et al.
The Journal of Biological Chemistry, 284(13), 8984-8994 (2009)
Rodell C Barrientos et al.
Journal of the American Society for Mass Spectrometry, 28(11), 2330-2343 (2017-08-24)
Glycosphingolipids are essential biomolecules widely distributed across biological kingdoms yet remain relatively underexplored owing to both compositional and structural complexity. While the glycan head group has been the subject of most studies, there is paucity of reports on the lipid

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