B2186

BL-1249

≥98% (HPLC)

• 别名: (5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine
• 经验公式（希尔记法）: C₁₇H₁₇N₅
• CAS号: 18200-13-0
• 分子量: 291.35
• MDL號碼: MFCD08276915
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724415
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 儲存條件: protect from light
• 顏色: pink to brown
• 溶解度: DMSO: ~17.5 mg/mL; H₂O: insoluble
• 儲存溫度: −20°C
• SMILES 字串: C1CCc2c(C1)cccc2Nc3ccccc3-c4nnn[nH]4
• InChI: 1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22)
• InChI 密鑰: YYNRZIFBTOUICE-UHFFFAOYSA-N

说明

一般說明

BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme.

應用

BL-1249 has been used:

• as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues
• as a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell line
• as a TREK1 and TREK2 activator in mice.

生化／生理作用

BL-1249 also activates TWIK related potassium channel 2 (TREK2). It interacts with K2P channel at the negatively charged activator site and modulates channel opening.

BL-1249 is a putative activator of potassium TREK-1 channel.

特點和優勢

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335,H413
• 防範說明: P273 - P302 + P352 - P305 + P351 + P338
• 危險分類: Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves