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Merck

B1651

Sigma-Aldrich

缓激肽片段 1-7

≥97% (HPLC)

别名:

1-7-Bradykinin

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About This Item

经验公式(希尔记法):
C35H52N10O9
CAS号:
分子量:
756.85
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26

product name

缓激肽片段 1-7, ≥97% (HPLC)

品質等級

化驗

≥97% (HPLC)

形狀

powder

顏色

white

UniProt登錄號

儲存溫度

−20°C

SMILES 字串

NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)N4CCCC4C(O)=O

InChI

1S/C35H52N10O9/c36-22(10-4-14-39-35(37)38)31(50)44-16-6-12-26(44)33(52)43-15-5-11-25(43)30(49)40-19-28(47)41-23(18-21-8-2-1-3-9-21)29(48)42-24(20-46)32(51)45-17-7-13-27(45)34(53)54/h1-3,8-9,22-27,46H,4-7,10-20,36H2,(H,40,49)(H,41,47)(H,42,48)(H,53,54)(H4,37,38,39)

InChI 密鑰

CRROPKNGCGVIOG-UHFFFAOYSA-N

基因資訊

rat ... Nppa(24602)

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro

一般說明

缓激肽片段1-7(BK-(1-7))是一种内源性肽,存在于血浆中。

應用

缓激肽片段1-7已被用作基质辅助激光解吸电离飞行时间质谱法(MALDI-TOF MS)蛋白质斑点分析中的外部校准物/标准品。
缓激肽片段1-7用于激肽酶的特异性和动力学研究。

生化/生理作用

缓激肽(BK)是一种促炎介质和神经介质。它可以调节多种血管和肾脏功能。缓激肽(BK)在诱导血管通透性和有丝分裂中起关键作用。它有助于在炎症和癌症组织中释放一氧化氮。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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C Shima et al.
Japanese journal of pharmacology, 60(2), 111-119 (1992-10-01)
Degradation of bradykinin (BK) in human plasma was investigated by searching for a stable metabolite as a marker of kinin release in vivo. BK, incubated with diluted plasma, was degraded to des-Arg9-BK (des-9-BK), des-Phe8-Arg9-BK (des-8,9-BK) and Arg-Pro-Pro-Gly-Phe ([1-5]BK). Des-9-BK was
M Katori et al.
British journal of pharmacology, 98(4), 1383-1391 (1989-12-01)
1. In vitro incubation of normal rat plasma with endotoxin from E. coli (3-10 mg ml-1) in the incubation mixture) caused a dose-dependent increase in levels of free kinin and plasma kallikrein in the presence of o-phenanthroline, together with a
Ch Golias et al.
Hippokratia, 11(3), 124-128 (2007-07-01)
The present review article regarding the kinin system-bradykinin is dealing with the biological effects of the abovementioned entity mediated by specific B1 and B2 receptors as well as with its clinical implications known nowadays. The activation of the kinin system-bradykinin
M Simmaco et al.
Biochimica et biophysica acta, 1033(3), 318-323 (1990-03-26)
The peptide fraction extracted by methanol from the skin of Rana esculenta, a species widely distributed in Western Europe, was investigated. The pharmacological activity found in the extract is attributable to the presence of authentic bradykinin, together with a shorter
L Germain et al.
Journal of the neurological sciences, 83(2-3), 211-217 (1988-02-01)
Experimental allergic encephalomyelitis (EAE) is a delayed cell-mediated autoimmune reaction to myelin basic protein. The neuropathology of this acute inflammatory process is characterized by cellular infiltration of the perivascular nervous parenchyma which increases the blood-brain barrier permeability. There is good

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