推荐产品
产品名称
血管紧张素片断 1-7 乙酸盐 水合物, ≥90% (HPLC), powder
品質等級
化驗
≥90% (HPLC)
形狀
powder
UniProt登錄號
儲存溫度
−20°C
SMILES 字串
CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(Cc2cnc[nH]2)C(=O)N3CCCC3C(O)=O
InChI
1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)
InChI 密鑰
PVHLMTREZMEJCG-UHFFFAOYSA-N
基因資訊
human ... AGT(183)
Amino Acid Sequence
Asp-Arg-Val-Tyr-Ile-His-Pro
應用
Angiotensin Fragment 1-7 acetate salt hydrate has been used:
- to evaluate its effects on a rat model of ventilator-induced diaphragmatic dysfunction (VIDD) with neuromuscular blocking agent infusion
- to unilaterally inject into the lateral preoptic area (LPA) to study its effects on intravesical pressure, arterial pressure, heart rate, and renal conductance in the female rats
- to study its association with influenza A virus (IAV) infection
生化／生理作用
Angiotensin fragment 1-7 is a biologically active heptapeptide of the renin-angiotensin system (RAS). It is associated with anti-inflammatory and anti-fibrotic effects in many inflammatory diseases such as asthma, dyslipidemia, renal injury, arthritis, and lung fibrosis. Angiotensin fragment 1-7 acts as a pro-resolving mediator and induces resolution of inflammation via Mas receptor (MasR). It is responsible for relaxation in several vascular beds. Angiotensin fragment 1-7 has a dual action of an angiotensin II type 1 (AT1) receptor agonist and antagonist depending on the presence of angiotensin II. It also serves as a substrate for angiotensin-converting enzyme (ACE). Sometimes, angiotensin fragment 1-7 prevents ACE activity leading to decreased angiotensin II generation and improved bradykinin-induced vasodilatation.
其他說明
Lyophilized from 0.5% acetic acid
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Differential responses to angiotensin-(1-7) in the feline mesenteric and hindquarters vascular beds.
S Y Osei et al.
European journal of pharmacology, 234(1), 35-42 (1993-03-30)
Regional vascular responses to angiotensin (Ang)-(1-7), a heptapeptide derivative of Ang II were investigated in the feline hindquarters and mesenteric vascular beds under conditions of controlled flow. In the mesenteric vascular bed, injections of Ang-(1-7) in doses of 1, 3
Vanessa Zambelli et al.
Intensive care medicine experimental, 7(1), 8-8 (2019-01-20)
Ventilator-induced diaphragmatic dysfunction (VIDD) is a common event during mechanical ventilation (MV) leading to rapid muscular atrophy and contractile dysfunction. Recent data show that renin-angiotensin system is involved in diaphragmatic skeletal muscle atrophy after MV. In particular, angiotensin-II can induce
Eliza M Melo et al.
Pharmacological research, 163, 105292-105292 (2020-11-11)
Resolution failure of exacerbated inflammation triggered by Influenza A virus (IAV) prevents return of pulmonary homeostasis and survival, especially when associated with secondary pneumococcal infection. Therapeutic strategies based on pro-resolving molecules have great potential against acute inflammatory diseases. Angiotensin-(1-7) [Ang-(1-7)]
C Caruso-Neves et al.
Biochimica et biophysica acta, 1467(1), 189-197 (2000-08-10)
Angiotensin-(1-7) (Ang-(1-7)) modulates the Na+-ATPase, but not the Na+,K+-ATPase activity present in pig kidney proximal tubules. The Na+-ATPase, insensitive to ouabain, but sensitive to furosemide, is stimulated by Ang-(1-7) (68% by 10(-9) M), in a dose-dependent manner. This effect is
Ilaria Caputo et al.
International journal of molecular sciences, 23(9) (2022-05-15)
Blockers of the renin-angiotensin system (RAS) have been reported to increase the angiotensin converting enzyme (ACE)2, the cellular receptor of SARS-CoV-2, and thus the risk and course of COVID-19. Therefore, we investigated if angiotensin (Ang) II and RAS blockers affected
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门