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![[Asn670, Leu671]-Amyloid β/A4 Precursor Protein 770 Fragment 667-676 trifluoroacetate salt ≥95% (HPLC), solid](/deepweb/assets/sigmaaldrich/product/images/296/089/259ad19e-25e1-4604-9077-8d4dbea518b6/640/259ad19e-25e1-4604-9077-8d4dbea518b6.jpg)
生物源
rabbit
共軛
agarose conjugate
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
human
分析物化學類別
proteins (c-Myc)
技術
affinity chromatography: suitable
immunoprecipitation (IP): suitable
容量
≥10 nmol/mL binding capacity (c-Myc tagged fusion protein)
≥7 nmol/mL elution capacity (c-Myc tagged fusion protein)
UniProt登錄號
儲存溫度
2-8°C
基因資訊
human ... MYC(4609)
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一般說明
人c-Myc原癌基因属于MYC癌基因家族，是在几种致白血病逆转录病毒中发现的禽v-Myc基因的人细胞同源物。c-Myc基因位于人类染色体8q24.21。其两个主结构域包括具有螺旋-环-螺旋/亮氨酸-拉链基序的N末端盒区域和C末端基本区域
特異性
抗c-Myc可识别位于c-Myc标记融合蛋白上的表位。
免疫原
人p62c-Myc蛋白的合成肽。
應用
兔源抗c-Myc琼脂糖亲和凝胶抗体已用于：
- 染色质免疫沉淀 (ChIP)
- 免疫共沉淀
- 蛋白质印迹
- 免疫荧光
- 免疫沉淀
生化／生理作用
许多人类肿瘤中观察到c-Myc原癌基因表达增加。在血管肉瘤中观察到Myc基因位点扩增，在伯基特氏淋巴瘤中Myc基因位点出现易位。c-Myc是主要的调控基因，可靶向多种代谢事件。位于人c-Myc氨基酸残基410-419（EQKLISEEDL）内的表位已在许多表达载体中广泛用作标签，使蛋白质能够作为c-Myc标记融合蛋白进行表达。抗c-Myc琼脂糖可用于纯化细菌裂解液或转染细胞中表达的c-Myc标记融合蛋白。
外觀
悬浮的琼脂糖颗粒(1：1，v/v)溶于0.01 M磷酸盐缓冲液中，含有15mM叠氮化钠。
儲存和穩定性
为持续使用并延长存储时间，请2°C至8°C存储。请勿冷冻。
其他說明
免責聲明
除非我们的产品目录另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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